Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ACR | ENSG00000100312 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TIMP4 | ENSG00000157150 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NR2C2 | ENSG00000177463 | 1.11 | 1.27 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| LYZL4 | ENSG00000157093 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IMPDH2 | ENSG00000178035 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 0.47 | 0.81 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| APEH | ENSG00000164062 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.00 | 0.64 | 1.23 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| SEMA3F | ENSG00000001617 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.00 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ITIH1 | ENSG00000055957 | 4.44 | 2.29 | 0.72 | 0.00 | 0.00 | 0.65 | 2.70 | 1.10 | 1.29 | 0.40 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.83 | 1.13 | 1.72 | 1.23 | 0.98 | 0.00 | 0.56 | 0.20 | 1.56 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| DNASE1L3 | ENSG00000163687 | 1.11 | 0.76 | 0.41 | 0.00 | 2.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PARP15 | ENSG00000173200 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.08 | 0.27 | 0.69 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| ALDH1L1 | ENSG00000144908 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.52 | 1.39 | 0.00 | 0.54 | 1.07 | 0.00 | 0.39 | 0.56 | 2.07 | 1.93 | 0.00 | 1.96 | 0.57 | 0.56 | 0.61 | 2.34 | 2.16 | 2.13 | 1.08 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PIK3R4 | ENSG00000196455 | 0.00 | 2.04 | 0.72 | 2.55 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.79 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.83 | 2.82 | 3.43 | 0.00 | 1.23 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| NEK11 | ENSG00000114670 | 0.00 | 2.80 | 0.62 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.11 | 1.88 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PCCB | ENSG00000114054 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| GRK7 | ENSG00000114124 | 0.00 | 0.76 | 0.41 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.56 | 1.32 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OTOL1 | ENSG00000182447 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 2.58 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 1.36 | 0.36 | 0.00 | 0.20 | 1.11 | 0.94 | 2.36 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 3.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OSTN | ENSG00000188729 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| PDE6B | ENSG00000133256 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 1.94 | 2.64 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| STK32B | ENSG00000152953 | 0.00 | 2.54 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.94 | 1.13 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 0.71 | 0.81 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| FDCSP | ENSG00000181617 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 1.47 | 0.20 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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