Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CSH2 | ENSG00000213218 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GH1 | ENSG00000259384 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MAP2K6 | ENSG00000108984 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| CDK3 | ENSG00000250506 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DCXR | ENSG00000169738 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TYMS | ENSG00000176890 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| ADCYAP1 | ENSG00000141433 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SERPINB11 | ENSG00000206072 | 1.11 | 1.02 | 0.41 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.28 | 1.69 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.92 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SERPINB7 | ENSG00000166396 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 1.03 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.78 | 0.00 | 1.69 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 4.50 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SERPINB8 | ENSG00000166401 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.54 | 0.00 | 0.00 | 0.39 | 0.28 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| CNDP2 | ENSG00000133313 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 1.42 | 0.00 | 0.00 | 0.83 | 0.94 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GPX4 | ENSG00000167468 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| THOP1 | ENSG00000172009 | 0.00 | 0.76 | 0.21 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.56 | 0.94 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| MATK | ENSG00000007264 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 1.55 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 1.11 | 1.32 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| MYDGF | ENSG00000074842 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TYK2 | ENSG00000105397 | 0.00 | 2.29 | 0.52 | 1.46 | 2.86 | 0.32 | 2.70 | 1.66 | 0.77 | 1.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.78 | 0.00 | 1.32 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.84 | 0.81 | 0.69 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| KLHL26 | ENSG00000167487 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.28 | 0.75 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 1.18 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| CAPN12 | ENSG00000182472 | 0.00 | 0.51 | 0.41 | 0.36 | 2.86 | 0.65 | 2.70 | 1.10 | 0.00 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| HIPK4 | ENSG00000160396 | 0.00 | 1.78 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| GSK3A | ENSG00000105723 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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