Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PTGR2 | ENSG00000140043 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.00 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| COQ6 | ENSG00000119723 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 0.38 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| RPS6KL1 | ENSG00000198208 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.32 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| VASH1 | ENSG00000071246 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SERPINA12 | ENSG00000165953 | 1.11 | 1.78 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.28 | 1.69 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| EIF2AK4 | ENSG00000128829 | 0.00 | 2.80 | 0.72 | 0.00 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.59 | 0.00 | 0.81 | 1.07 | 0.74 | 0.20 | 1.94 | 1.13 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 1.36 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| PLA2G4B | ENSG00000243708 | 1.11 | 1.78 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 1.66 | 0.26 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TTBK2 | ENSG00000128881 | 0.00 | 2.04 | 0.31 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.98 | 0.83 | 0.56 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 3.32 | 2.44 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| TGM5 | ENSG00000104055 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.77 | 0.60 | 0.00 | 1.90 | 0.00 | 0.74 | 0.59 | 0.56 | 0.75 | 1.72 | 0.00 | 0.25 | 1.15 | 0.56 | 0.00 | 0.78 | 0.00 | 2.61 | 1.63 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| SORD | ENSG00000140263 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SMAD3 | ENSG00000166949 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 3.55 | 0.00 | 1.66 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 1.32 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 3.13 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CLK3 | ENSG00000179335 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.81 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ULK3 | ENSG00000140474 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| BCL2A1 | ENSG00000140379 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RLBP1 | ENSG00000140522 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| C1QTNF8 | ENSG00000184471 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| NPW | ENSG00000183971 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DNASE1L2 | ENSG00000167968 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PRSS33 | ENSG00000103355 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PLK1 | ENSG00000166851 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.97 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 2.44 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
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