Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| LRRK2 | ENSG00000188906 | 1.11 | 7.38 | 1.45 | 4.01 | 0.00 | 3.55 | 2.70 | 7.73 | 1.55 | 4.58 | 0.00 | 1.90 | 1.42 | 1.47 | 0.00 | 3.33 | 3.39 | 12.02 | 1.23 | 4.17 | 1.15 | 0.00 | 1.22 | 4.69 | 1.72 | 5.92 | 11.38 | 1.39 | 0.61 | 0.00 | 5.99 | 1.82 | 0.00 |
| SENP1 | ENSG00000079387 | 0.00 | 0.25 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CCNT1 | ENSG00000129315 | 0.00 | 1.27 | 0.41 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.80 | 1.54 | 0.27 | 0.36 | 2.21 | 0.20 | 0.56 | 0.75 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.81 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| DCD | ENSG00000161634 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TAC3 | ENSG00000166863 | 1.11 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| WIF1 | ENSG00000156076 | 1.11 | 1.27 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 2.21 | 0.39 | 1.39 | 0.38 | 2.36 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 1.29 | 1.66 | 0.54 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 |
| LYZ | ENSG00000090382 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| UBE2N | ENSG00000177889 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SCYL2 | ENSG00000136021 | 1.11 | 1.02 | 0.72 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.28 | 1.69 | 3.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| PMCH | ENSG00000183395 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ALDH1L2 | ENSG00000136010 | 1.11 | 1.02 | 0.83 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 0.94 | 1.29 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ALDH2 | ENSG00000111275 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 1.25 |
| ULK1 | ENSG00000177169 | 0.00 | 2.04 | 0.10 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 1.32 | 2.36 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 1.29 | 3.08 | 1.90 | 0.69 | 0.00 | 0.00 | 2.66 | 1.82 | 0.00 |
| C1QTNF9B | ENSG00000205863 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| DHRS12 | ENSG00000102796 | 0.00 | 0.25 | 0.10 | 1.09 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DHRS2 | ENSG00000100867 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| COCH | ENSG00000100473 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 1.66 | 0.00 | 0.80 | 1.54 | 0.00 | 1.42 | 0.00 | 0.20 | 0.00 | 0.75 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| KLHL28 | ENSG00000179454 | 1.11 | 1.27 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CDKL1 | ENSG00000100490 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAP3K9 | ENSG00000006432 | 0.00 | 2.54 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.79 | 0.00 | 0.27 | 0.00 | 1.47 | 0.20 | 0.83 | 2.64 | 1.50 | 1.23 | 0.25 | 0.57 | 0.00 | 0.20 | 1.56 | 0.86 | 6.16 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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