Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| STK32C | ENSG00000165752 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| CHID1 | ENSG00000177830 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| INS | ENSG00000254647 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR51C1P | ENSG00000197674 | |||||||||||||||||||||||||||||||||
| WEE1 | ENSG00000166483 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADM | ENSG00000148926 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| PTH | ENSG00000152266 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CALCB | ENSG00000175868 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| SAA2 | ENSG00000134339 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CRY2 | ENSG00000121671 | 1.11 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 2.13 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MDK | ENSG00000110492 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| EFEMP2 | ENSG00000172638 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| CLCF1 | ENSG00000175505 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GAL | ENSG00000069482 | 0.00 | 0.00 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PPME1 | ENSG00000214517 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GUCY1A2 | ENSG00000152402 | 0.00 | 2.04 | 0.72 | 1.46 | 0.00 | 0.65 | 0.00 | 2.76 | 0.26 | 1.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 3.77 | 4.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.81 | 2.34 | 0.00 | 5.92 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ADAMTS8 | ENSG00000134917 | 1.11 | 1.02 | 0.00 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.77 | 1.20 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 0.56 | 1.29 | 0.00 | 0.49 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 2.61 | 1.63 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 0.00 |
| FGF23 | ENSG00000118972 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MGP | ENSG00000111341 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RECQL | ENSG00000004700 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 2.21 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.13 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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