Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CRISP2 | ENSG00000124490 | 1.11 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.32 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.55 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| DEFB114 | ENSG00000177684 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HDAC2 | ENSG00000196591 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.59 | 0.83 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LATS1 | ENSG00000131023 | 0.00 | 3.05 | 0.72 | 3.28 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 1.39 | 1.88 | 3.65 | 2.47 | 1.96 | 1.15 | 0.00 | 0.00 | 1.56 | 0.00 | 1.42 | 1.63 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| RPS6KA2 | ENSG00000071242 | 0.00 | 1.53 | 0.83 | 0.36 | 0.00 | 1.94 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.56 | 1.72 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 1.63 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| IGFBP1 | ENSG00000146678 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| DEFB103A | ENSG00000176797 | |||||||||||||||||||||||||||||||||
| LOXL2 | ENSG00000134013 | 1.11 | 1.78 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 4.74 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC25A37 | ENSG00000147454 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| POLB | ENSG00000070501 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 1.08 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRKDC | ENSG00000253729 | 1.11 | 5.34 | 2.38 | 4.74 | 2.86 | 1.94 | 2.70 | 5.52 | 1.03 | 4.58 | 0.00 | 2.17 | 2.14 | 0.74 | 0.98 | 5.56 | 7.16 | 6.87 | 1.23 | 1.72 | 0.57 | 0.00 | 1.22 | 3.91 | 3.02 | 5.45 | 3.52 | 0.69 | 0.81 | 0.00 | 8.65 | 0.00 | 0.00 |
| PDE7A | ENSG00000205268 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ATP6V1C1 | ENSG00000155097 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| COLEC10 | ENSG00000184374 | 1.11 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CYP11B2 | ENSG00000179142 | 0.00 | 2.54 | 0.83 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.11 | 4.14 | 2.58 | 0.00 | 1.23 | 0.57 | 0.56 | 0.41 | 0.00 | 0.43 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| IFNB1 | ENSG00000171855 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ALDH1A1 | ENSG00000165092 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.32 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| IARS | ENSG00000196305 | 1.11 | 0.76 | 1.14 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 1.03 | 1.79 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.00 | 1.13 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 1.36 | 0.00 | 0.61 | 0.00 | 2.22 | 0.00 | 0.00 |
| COL27A1 | ENSG00000196739 | 0.00 | 2.04 | 0.72 | 1.82 | 0.00 | 4.19 | 2.70 | 1.66 | 0.77 | 1.39 | 1.54 | 1.36 | 0.71 | 0.74 | 0.59 | 1.39 | 2.64 | 2.58 | 1.23 | 1.23 | 0.57 | 0.00 | 0.61 | 0.78 | 0.00 | 5.21 | 1.90 | 0.00 | 0.00 | 0.00 | 3.33 | 1.82 | 1.25 |
| TOR2A | ENSG00000160404 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
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