Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GHRL | ENSG00000157017 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TGM4 | ENSG00000163810 | 0.00 | 1.53 | 0.21 | 1.09 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 1.59 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.56 | 2.45 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 3.08 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 1.25 |
| LARS2 | ENSG00000011376 | 1.11 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| PRSS50 | ENSG00000206549 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PRSS45 | ENSG00000188086 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| UCN2 | ENSG00000145040 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| BAP1 | ENSG00000163930 | 0.00 | 2.80 | 1.03 | 2.92 | 17.14 | 0.97 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 10.30 | 4.63 | 0.00 | 0.00 | 5.56 | 1.13 | 0.64 | 20.99 | 0.98 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.81 | 0.69 | 0.00 | 0.83 | 2.00 | 0.00 | 16.25 |
| FAM19A1 | ENSG00000183662 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PROK2 | ENSG00000163421 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PDIA5 | ENSG00000065485 | 0.00 | 1.78 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.36 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 1.25 |
| TXNRD3 | ENSG00000197763 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| AADACL2 | ENSG00000197953 | 0.00 | 1.02 | 0.41 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.56 | 1.32 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| UTS2B | ENSG00000188958 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| BDH1 | ENSG00000161267 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.56 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| GRK4 | ENSG00000125388 | 1.11 | 0.51 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| NMU | ENSG00000109255 | 0.00 | 0.76 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| UBA6 | ENSG00000033178 | 0.00 | 2.54 | 0.62 | 0.73 | 0.00 | 0.65 | 5.41 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 1.39 | 3.20 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 0.27 | 0.00 | 0.20 | 0.83 | 2.44 | 0.00 | 0.00 |
| PF4 | ENSG00000163737 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PPBP | ENSG00000163736 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CXCL11 | ENSG00000169248 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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