Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC25A12 | ENSG00000115840 | 0.00 | 2.04 | 0.21 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 1.67 | 1.51 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| FRZB | ENSG00000162998 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 1.32 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IGFBP2 | ENSG00000115457 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SPEG | ENSG00000072195 | 1.11 | 3.31 | 1.14 | 2.55 | 2.86 | 2.58 | 0.00 | 0.55 | 2.32 | 1.99 | 0.00 | 0.27 | 1.42 | 0.74 | 0.78 | 4.17 | 6.59 | 4.94 | 0.00 | 1.47 | 0.00 | 0.00 | 1.02 | 3.13 | 0.86 | 8.77 | 2.71 | 0.00 | 0.00 | 2.48 | 6.87 | 0.00 | 2.50 |
| COL4A3 | ENSG00000169031 | 0.00 | 2.80 | 1.14 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 1.55 | 3.19 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.83 | 1.51 | 3.86 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 1.72 | 8.06 | 1.63 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| SPP2 | ENSG00000072080 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| STK35 | ENSG00000125834 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 1.23 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SMOX | ENSG00000088826 | 0.00 | 1.27 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.69 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| PAK7 | ENSG00000101349 | 2.22 | 1.02 | 0.10 | 0.73 | 0.00 | 1.61 | 2.70 | 0.55 | 1.29 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.94 | 5.08 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 11.37 | 0.81 | 0.00 | 0.41 | 0.00 | 0.44 | 0.00 | 0.00 |
| PCSK2 | ENSG00000125851 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 0.97 | 2.70 | 1.66 | 1.03 | 1.79 | 0.00 | 0.81 | 0.71 | 0.74 | 1.18 | 0.56 | 1.88 | 2.58 | 1.23 | 1.96 | 1.15 | 0.00 | 1.02 | 0.78 | 0.43 | 1.66 | 1.90 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| CST11 | ENSG00000125831 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MYLK2 | ENSG00000101306 | 2.22 | 1.53 | 0.41 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SGK2 | ENSG00000101049 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 1.08 | 1.42 | 0.00 | 0.20 | 0.28 | 1.32 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| STK4 | ENSG00000101109 | 1.11 | 1.27 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MOCS3 | ENSG00000124217 | 0.00 | 1.78 | 0.00 | 1.46 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.28 | 1.51 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SYNJ1 | ENSG00000159082 | 1.11 | 3.82 | 0.62 | 0.73 | 2.86 | 0.00 | 0.00 | 2.76 | 0.52 | 2.19 | 0.00 | 1.36 | 0.00 | 0.74 | 0.39 | 1.67 | 2.07 | 1.93 | 1.23 | 1.96 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 3.32 | 0.81 | 0.69 | 0.00 | 0.00 | 4.21 | 0.00 | 0.00 |
| TFF3 | ENSG00000160180 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CSNK1E | ENSG00000213923 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 1.11 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CHADL | ENSG00000100399 | 0.00 | 0.00 | 0.10 | 0.36 | 2.86 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PIM3 | ENSG00000198355 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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