Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CAMKK1 | ENSG00000004660 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.18 | 0.27 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| NEK8 | ENSG00000160602 | 0.00 | 1.27 | 0.72 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.38 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.41 | 0.83 | 0.89 | 0.00 | 0.00 |
| WNT9B | ENSG00000158955 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 3.64 | 0.00 |
| TLK2 | ENSG00000146872 | 0.00 | 2.04 | 0.52 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.11 | 1.32 | 1.72 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CSH1 | ENSG00000136488 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CSHL1 | ENSG00000204414 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.56 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MAPK4 | ENSG00000141639 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 1.32 | 1.72 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.50 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 0.00 |
| STK11 | ENSG00000118046 | 1.11 | 0.00 | 0.21 | 4.74 | 2.86 | 0.32 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 12.99 | 1.07 | 0.00 | 0.00 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CSNK1G2 | ENSG00000133275 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MKNK2 | ENSG00000099875 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CARM1 | ENSG00000142453 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MAST3 | ENSG00000099308 | 1.11 | 1.27 | 0.41 | 1.46 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.78 | 0.56 | 1.69 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| TSSK6 | ENSG00000178093 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| IFNL3 | ENSG00000197110 | 0.00 | 0.25 | 0.21 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| IFNL2 | ENSG00000183709 | 0.00 | 0.51 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 1.29 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PTH2 | ENSG00000142538 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GKN2 | ENSG00000183607 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MAP3K19 | ENSG00000176601 | 1.11 | 1.27 | 0.62 | 1.82 | 0.00 | 1.29 | 0.00 | 1.10 | 2.06 | 3.39 | 0.00 | 0.54 | 1.78 | 0.74 | 0.78 | 1.11 | 2.64 | 3.86 | 0.00 | 2.21 | 0.57 | 0.00 | 0.20 | 1.56 | 1.29 | 4.98 | 0.54 | 0.00 | 0.20 | 0.00 | 2.88 | 5.45 | 2.50 |
| MYO3B | ENSG00000071909 | 1.11 | 2.54 | 0.62 | 1.46 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 1.59 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 1.67 | 2.45 | 2.58 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 5.69 | 1.90 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 1.25 |
| TLK1 | ENSG00000198586 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 1.00 | 1.54 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.32 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
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