Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC25A21 | ENSG00000183032 | 0.00 | 0.00 | 0.10 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CDKN3 | ENSG00000100526 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RDH12 | ENSG00000139988 | 0.00 | 0.51 | 0.10 | 0.36 | 2.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADCK1 | ENSG00000063761 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| RPS6KA5 | ENSG00000100784 | 0.00 | 2.29 | 0.41 | 1.09 | 0.00 | 0.32 | 2.70 | 1.66 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 1.11 | 1.51 | 1.50 | 0.00 | 0.49 | 0.00 | 0.56 | 0.41 | 0.00 | 0.00 | 1.42 | 0.27 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC25A29 | ENSG00000197119 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MOK | ENSG00000080823 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| BUB1B | ENSG00000156970 | 0.00 | 1.78 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 0.00 | 1.32 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PLA2G4D | ENSG00000159337 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 3.79 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| GANC | ENSG00000214013 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.19 | 1.72 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ALDH1A2 | ENSG00000128918 | 0.00 | 1.27 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LACTB | ENSG00000103642 | 1.11 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.56 | 0.38 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DPP8 | ENSG00000074603 | 0.00 | 2.29 | 0.41 | 2.19 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| CYP11A1 | ENSG00000140459 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.28 | 0.94 | 1.29 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.54 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| ALDH1A3 | ENSG00000184254 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.21 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.78 | 0.86 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| C16orf89 | ENSG00000153446 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 1.23 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ABAT | ENSG00000183044 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 1.51 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 0.81 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| IL27 | ENSG00000197272 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.94 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CES3 | ENSG00000172828 | 0.00 | 1.27 | 0.00 | 1.09 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.28 | 1.13 | 0.43 | 0.00 | 1.23 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 3.55 | 0.00 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CLEC3A | ENSG00000166509 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
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