Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TRRAP | ENSG00000196367 | 0.00 | 7.89 | 1.14 | 2.92 | 0.00 | 1.94 | 0.00 | 6.08 | 2.32 | 4.18 | 1.54 | 0.81 | 0.36 | 0.74 | 1.18 | 1.39 | 5.08 | 6.01 | 0.00 | 2.21 | 0.57 | 0.56 | 0.61 | 2.34 | 2.16 | 10.43 | 5.42 | 0.00 | 0.20 | 0.00 | 7.32 | 1.82 | 0.00 |
| HIPK2 | ENSG00000064393 | 0.00 | 1.53 | 0.62 | 0.36 | 0.00 | 1.29 | 0.00 | 2.21 | 1.29 | 0.60 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 1.94 | 1.51 | 1.93 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| DEFB103B | ENSG00000177243 | |||||||||||||||||||||||||||||||||
| NAT2 | ENSG00000156006 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HTRA4 | ENSG00000169495 | 0.00 | 0.00 | 0.00 | 0.00 | 2.86 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.13 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| PSKH2 | ENSG00000147613 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 3.20 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CYP11B1 | ENSG00000160882 | 0.00 | 1.02 | 0.62 | 0.36 | 0.00 | 1.94 | 2.70 | 1.10 | 0.26 | 1.20 | 1.54 | 0.00 | 0.71 | 0.00 | 0.00 | 1.67 | 3.39 | 4.51 | 0.00 | 1.96 | 0.57 | 0.56 | 0.20 | 1.56 | 0.43 | 3.08 | 2.44 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| MSMP | ENSG00000215183 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DHRSX | ENSG00000169084 | 0.00 | 0.76 | 0.00 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PIM2 | ENSG00000102096 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.86 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PAK3 | ENSG00000077264 | 2.22 | 2.80 | 0.21 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.83 | 1.88 | 1.50 | 0.00 | 1.96 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.13 | 0.81 | 0.69 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ALDH4A1 | ENSG00000159423 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 1.13 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| PLA2G2D | ENSG00000117215 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLA2G2C | ENSG00000187980 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RPS6KA1 | ENSG00000117676 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.59 | 0.56 | 0.56 | 1.50 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TSSK3 | ENSG00000162526 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| COL9A2 | ENSG00000049089 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 2.15 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 3.08 | 0.27 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 2.50 |
| TXNDC12 | ENSG00000117862 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC25A24 | ENSG00000085491 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 1.29 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CHI3L2 | ENSG00000064886 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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