Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC17A5 | ENSG00000119899 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.00 | 0.38 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC26A2 | ENSG00000155850 | 2.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PCDHB10 | ENSG00000120324 | 1.11 | 2.80 | 0.41 | 0.36 | 0.00 | 0.97 | 2.70 | 1.66 | 0.00 | 1.79 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 1.67 | 4.71 | 4.08 | 1.23 | 1.47 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 4.27 | 2.44 | 0.00 | 0.20 | 0.00 | 3.10 | 3.64 | 0.00 |
| ADRB2 | ENSG00000169252 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC43A2 | ENSG00000167703 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADGRG6 | ENSG00000112414 | 1.11 | 2.04 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.39 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.28 | 1.69 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 2.34 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| NRG2 | ENSG00000158458 | 0.00 | 0.25 | 0.10 | 0.00 | 2.86 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.86 | 1.23 | 0.74 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 2.61 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD74 | ENSG00000019582 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 1.10 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SLC36A1 | ENSG00000123643 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ITFG3 | ENSG00000167930 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 1.23 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HBEGF | ENSG00000113070 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MAN2A1 | ENSG00000112893 | 1.11 | 3.31 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 2.78 | 2.64 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| SLC37A3 | ENSG00000157800 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.32 | 5.41 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SLC16A10 | ENSG00000112394 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ADORA3 | ENSG00000121933 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC13A5 | ENSG00000141485 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 2.70 | 0.00 | 0.00 | 0.40 | 1.54 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.00 | 0.43 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| NGF | ENSG00000134259 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.64 | 0.00 | 0.00 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 1.90 | 0.81 | 0.00 | 0.20 | 0.83 | 0.22 | 0.00 | 0.00 |
| SERPINF2 | ENSG00000167711 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ULBP2 | ENSG00000131015 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.69 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| SLC18B1 | ENSG00000146409 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 1.25 |
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