Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CAMP | ENSG00000164047 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MAPKAPK3 | ENSG00000114738 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| IL12A | ENSG00000168811 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 1.11 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GAK | ENSG00000178950 | 1.11 | 2.80 | 0.21 | 0.36 | 0.00 | 0.97 | 2.70 | 0.00 | 0.26 | 1.59 | 1.54 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 1.69 | 1.72 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 1.56 | 0.00 | 1.66 | 1.63 | 0.00 | 0.20 | 0.83 | 2.00 | 0.00 | 0.00 |
| HSD17B13 | ENSG00000170509 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TBCK | ENSG00000145348 | 0.00 | 0.76 | 0.21 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.79 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.75 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PRSS48 | ENSG00000189099 | 0.00 | 0.76 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAP3K1 | ENSG00000095015 | 2.22 | 2.29 | 8.68 | 1.46 | 0.00 | 1.94 | 0.00 | 3.31 | 1.55 | 0.80 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 1.11 | 0.94 | 2.15 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.41 | 0.83 | 6.43 | 1.82 | 0.00 |
| CDK7 | ENSG00000134058 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.00 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CAMK4 | ENSG00000152495 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 2.45 | 1.07 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 3.08 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PPIC | ENSG00000168938 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| CLK4 | ENSG00000113240 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.54 | 1.78 | 0.00 | 0.20 | 1.39 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MYLK4 | ENSG00000145949 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.13 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PRSS16 | ENSG00000112812 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 1.55 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 0.94 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 1.29 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| VARS2 | ENSG00000137411 | 0.00 | 3.05 | 0.21 | 0.36 | 0.00 | 0.97 | 2.70 | 0.00 | 0.77 | 0.60 | 1.54 | 1.08 | 1.42 | 1.47 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 2.17 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| LTA | ENSG00000226979 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DDO | ENSG00000203797 | 1.11 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| FAM20C | ENSG00000177706 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 1.54 | 0.00 | 2.14 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| DDC | ENSG00000132437 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.00 | 2.70 | 1.10 | 1.29 | 1.20 | 1.54 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 2.15 | 1.23 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.81 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PHKG1 | ENSG00000164776 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.00 | 0.94 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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