Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CGREF1 | ENSG00000138028 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GKN1 | ENSG00000169605 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.51 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GFPT1 | ENSG00000198380 | 0.00 | 0.25 | 0.52 | 2.19 | 0.00 | 0.32 | 2.70 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| TTN | ENSG00000155657 | 12.22 | 44.27 | 17.15 | 28.47 | 14.29 | 44.52 | 10.81 | 39.78 | 24.74 | 40.44 | 4.62 | 19.51 | 16.37 | 5.88 | 11.57 | 27.50 | 44.44 | 70.82 | 13.58 | 27.45 | 16.67 | 2.25 | 10.59 | 45.31 | 11.64 | 71.33 | 45.80 | 4.86 | 3.67 | 4.96 | 31.26 | 12.73 | 5.00 |
| CLK1 | ENSG00000013441 | 2.22 | 1.53 | 0.21 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.42 | 0.00 | 0.69 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| STRADB | ENSG00000082146 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CYP27A1 | ENSG00000135929 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DNPEP | ENSG00000123992 | 1.11 | 0.25 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 1.13 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 2.34 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCG2 | ENSG00000171951 | 0.00 | 2.54 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 2.76 | 1.03 | 0.40 | 0.00 | 1.08 | 0.71 | 0.00 | 0.00 | 0.83 | 2.45 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 1.90 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CST9 | ENSG00000173335 | 2.22 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 |
| CST3 | ENSG00000101439 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| WFDC8 | ENSG00000158901 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| CBR1 | ENSG00000159228 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| SIK1 | ENSG00000142178 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.83 | 1.13 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| LSS | ENSG00000160285 | 0.00 | 1.53 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.56 | 0.75 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.41 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| CHEK2 | ENSG00000183765 | 2.22 | 1.78 | 0.62 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 1.51 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.81 | 0.83 | 2.22 | 1.82 | 0.00 |
| INPP5J | ENSG00000185133 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 1.29 | 0.60 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CAMK1 | ENSG00000134072 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NEK10 | ENSG00000163491 | 0.00 | 2.04 | 0.52 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 1.03 | 1.00 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 1.39 | 2.07 | 1.72 | 0.00 | 1.72 | 1.72 | 0.00 | 0.00 | 1.56 | 0.43 | 1.42 | 2.71 | 1.39 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC25A38 | ENSG00000144659 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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