Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TSSK1B | ENSG00000212122 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 1.61 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 1.13 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 3.79 | 0.27 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| CYP21A2 | ENSG00000231852 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.00 | 1.54 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PLA2G7 | ENSG00000146070 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| NPY | ENSG00000122585 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| CAPZA2 | ENSG00000198898 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FAM3C | ENSG00000196937 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.41 | 0.00 | 0.22 | 0.00 | 0.00 |
| DEFB4A | ENSG00000171711 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PEBP4 | ENSG00000134020 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RRM2B | ENSG00000048392 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTGS1 | ENSG00000095303 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 2.64 | 1.29 | 0.00 | 0.49 | 0.00 | 0.56 | 0.41 | 0.78 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CEL | ENSG00000170835 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 1.29 | 2.13 | 0.27 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| STKLD1 | ENSG00000198870 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.38 | 1.29 | 2.47 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ARSD | ENSG00000006756 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 1.54 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 0.94 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| NRK | ENSG00000123572 | 1.11 | 1.02 | 1.55 | 2.55 | 2.86 | 3.23 | 2.70 | 2.21 | 1.55 | 1.99 | 0.00 | 0.27 | 1.07 | 0.00 | 0.39 | 0.28 | 4.90 | 6.01 | 1.23 | 0.74 | 2.30 | 0.00 | 0.20 | 3.13 | 0.86 | 9.95 | 3.52 | 0.00 | 0.00 | 0.83 | 4.66 | 1.82 | 0.00 |
| AIFM1 | ENSG00000156709 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 1.54 | 0.54 | 0.00 | 0.00 | 0.39 | 0.83 | 2.45 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.83 | 0.89 | 1.82 | 0.00 |
| DRAXIN | ENSG00000162490 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| C1QB | ENSG00000173369 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PDIK1L | ENSG00000175087 | 0.00 | 0.76 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| STK40 | ENSG00000196182 | 0.00 | 0.25 | 0.31 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GUCA2B | ENSG00000044012 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
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