Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TRIB2 | ENSG00000071575 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CYP26B1 | ENSG00000003137 | 0.00 | 1.53 | 0.52 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.28 | 3.39 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PPIL3 | ENSG00000240344 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADAMTS1 | ENSG00000154734 | 0.00 | 0.25 | 0.62 | 1.82 | 0.00 | 1.94 | 2.70 | 1.10 | 0.77 | 0.80 | 1.54 | 0.27 | 0.71 | 1.47 | 0.20 | 0.83 | 2.45 | 0.21 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.00 | 2.17 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| APOL1 | ENSG00000100342 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CYB5R3 | ENSG00000100243 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FAM19A5 | ENSG00000219438 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| DCLK3 | ENSG00000163673 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.74 | 0.59 | 0.00 | 3.58 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 4.03 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ULK4 | ENSG00000168038 | 0.00 | 2.29 | 0.52 | 1.09 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 2.64 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.61 | 2.34 | 0.86 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC25A26 | ENSG00000144741 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TERT | ENSG00000164362 | 1.11 | 0.51 | 0.52 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.81 | 1.42 | 0.00 | 0.39 | 0.56 | 0.56 | 1.50 | 1.23 | 0.25 | 1.15 | 0.00 | 0.00 | 0.78 | 0.86 | 1.90 | 0.54 | 0.00 | 0.61 | 0.00 | 1.33 | 0.00 | 0.00 |
| CRISP3 | ENSG00000096006 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 1.10 | 0.77 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 1.88 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GCLC | ENSG00000001084 | 0.00 | 1.78 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 1.51 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| IFNK | ENSG00000147896 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HSD17B3 | ENSG00000130948 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.00 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 0.00 |
| APOO | ENSG00000184831 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC25A33 | ENSG00000171612 | 0.00 | 0.00 | 0.00 | 0.00 | 2.86 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| HIPK1 | ENSG00000163349 | 0.00 | 1.78 | 0.31 | 1.82 | 0.00 | 0.32 | 2.70 | 1.10 | 1.29 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 1.11 | 1.88 | 1.50 | 0.00 | 1.72 | 0.00 | 0.00 | 0.61 | 0.00 | 0.86 | 1.66 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| CYP2C8 | ENSG00000138115 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 1.11 | 0.38 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.81 | 0.78 | 0.00 | 5.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| BRSK2 | ENSG00000174672 | 1.11 | 1.02 | 0.31 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
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