Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GPR19 | ENSG00000183150 | 2.22 | 0.25 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNQ1 | ENSG00000053918 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| GRN | ENSG00000030582 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| SLC22A18 | ENSG00000110628 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD68 | ENSG00000129226 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OLFML3 | ENSG00000116774 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.00 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC38A7 | ENSG00000103042 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| ITGA2B | ENSG00000005961 | 0.00 | 2.80 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.83 | 1.32 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TNFSF12 | ENSG00000239697 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NLGN2 | ENSG00000169992 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 0.28 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.54 | 0.69 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| CHRNB1 | ENSG00000170175 | 0.00 | 1.02 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.28 | 0.75 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FKTN | ENSG00000106692 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.00 | 1.54 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| SLC31A1 | ENSG00000136868 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ABCA7 | ENSG00000064687 | 1.11 | 2.04 | 0.93 | 2.19 | 0.00 | 0.00 | 2.70 | 0.55 | 0.77 | 1.59 | 0.00 | 1.63 | 2.14 | 0.00 | 0.98 | 1.94 | 2.45 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 2.37 | 1.36 | 0.69 | 0.00 | 1.65 | 3.33 | 1.82 | 0.00 |
| SLC22A3 | ENSG00000146477 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.03 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 2.00 | 1.82 | 0.00 |
| SLC16A11 | ENSG00000174326 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ASGR1 | ENSG00000141505 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ITFG1 | ENSG00000129636 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| IL20RA | ENSG00000016402 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC22A23 | ENSG00000137266 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 5.41 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.28 | 0.56 | 0.86 | 1.23 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
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