Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC39A13 | ENSG00000165915 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 1.65 | 0.67 | 0.00 | 0.00 |
| SLC22A10 | ENSG00000184999 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.40 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.28 | 0.56 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RTN3 | ENSG00000133318 | 0.00 | 1.27 | 0.52 | 1.09 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.00 | 1.69 | 0.43 | 2.47 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 3.08 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ENDOD1 | ENSG00000149218 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.75 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC37A4 | ENSG00000137700 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC48A1 | ENSG00000211584 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TMPRSS12 | ENSG00000186452 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SOAT2 | ENSG00000167780 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| DYRK2 | ENSG00000127334 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.20 | 0.83 | 1.33 | 0.00 | 0.00 |
| SLC35E3 | ENSG00000175782 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| TPTE2 | ENSG00000132958 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.65 | 0.00 | 2.21 | 2.32 | 0.40 | 0.00 | 1.08 | 0.36 | 0.00 | 0.59 | 0.56 | 1.13 | 2.58 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 2.34 | 0.00 | 7.11 | 2.71 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SERPINA9 | ENSG00000170054 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 2.26 | 1.29 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 1.25 |
| CHRFAM7A | ENSG00000166664 | 1.11 | 0.00 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC30A4 | ENSG00000104154 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TRPM7 | ENSG00000092439 | 1.11 | 1.53 | 0.41 | 1.09 | 0.00 | 1.29 | 2.70 | 1.10 | 0.52 | 1.99 | 1.54 | 0.81 | 1.42 | 0.00 | 0.20 | 1.39 | 1.51 | 2.79 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| NOX5 | ENSG00000255346 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.88 | 2.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 4.03 | 0.81 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| CLCN7 | ENSG00000103249 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 1.08 | 0.71 | 0.00 | 0.39 | 0.83 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| ATP2A1 | ENSG00000196296 | 1.11 | 2.29 | 0.83 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 1.23 | 1.15 | 0.56 | 0.41 | 3.13 | 0.43 | 1.18 | 0.81 | 0.69 | 0.00 | 0.00 | 3.55 | 0.00 | 0.00 |
| ALDOA | ENSG00000149925 | 0.00 | 1.53 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| VKORC1 | ENSG00000167397 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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