Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CYP19A1 | ENSG00000137869 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.00 | 0.75 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 3.79 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| CSNK1G1 | ENSG00000169118 | 1.11 | 1.27 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CYP1A2 | ENSG00000140505 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.77 | 0.60 | 1.54 | 0.27 | 0.71 | 0.00 | 0.39 | 0.00 | 0.75 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| SDR42E2 | ENSG00000183921 | |||||||||||||||||||||||||||||||||
| SDR42E1 | ENSG00000184860 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 1.54 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 1.13 | 0.86 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ERN1 | ENSG00000178607 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| CYP4F22 | ENSG00000171954 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 1.03 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.75 | 1.29 | 0.00 | 0.49 | 1.72 | 0.00 | 0.20 | 1.56 | 0.00 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| EIF2AK3 | ENSG00000172071 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 1.94 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.56 | 1.88 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.81 | 0.00 | 0.86 | 2.37 | 2.98 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| UGT1A8 | ENSG00000242366 | |||||||||||||||||||||||||||||||||
| UGT1A10 | ENSG00000242515 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 1.88 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| UGT1A7 | ENSG00000244122 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 0.94 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| UGT1A5 | ENSG00000240224 | 1.11 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.00 | 1.13 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| UGT1A4 | ENSG00000244474 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 1.07 | 0.00 | 0.49 | 1.15 | 0.00 | 0.20 | 0.78 | 0.86 | 2.61 | 1.36 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| UGT1A3 | ENSG00000243135 | 1.11 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| UGT1A1 | ENSG00000241635 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 0.19 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CYP2D6 | ENSG00000100197 | 0.00 | 0.76 | 0.31 | 0.00 | 2.86 | 0.32 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| UGT2B17 | ENSG00000197888 | 0.00 | 1.53 | 0.00 | 1.46 | 2.86 | 0.65 | 2.70 | 0.55 | 0.77 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.88 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 5.45 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| UGT2B4 | ENSG00000156096 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 2.06 | 2.59 | 0.00 | 0.27 | 0.00 | 1.47 | 0.78 | 1.39 | 3.39 | 1.50 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 8.53 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC35D3 | ENSG00000182747 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| SMOC2 | ENSG00000112562 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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