Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CPE | ENSG00000109472 | 0.00 | 1.53 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 0.64 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CASP3 | ENSG00000164305 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.94 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| C6 | ENSG00000039537 | 1.11 | 1.53 | 0.72 | 1.82 | 0.00 | 1.94 | 2.70 | 1.66 | 1.03 | 3.19 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.00 | 3.20 | 9.66 | 0.00 | 0.98 | 0.57 | 0.00 | 0.81 | 0.78 | 1.72 | 17.30 | 1.63 | 0.00 | 0.20 | 0.00 | 3.99 | 0.00 | 0.00 |
| PIK3R1 | ENSG00000145675 | 0.00 | 1.27 | 2.48 | 1.82 | 0.00 | 2.26 | 0.00 | 1.66 | 9.54 | 1.59 | 0.00 | 0.54 | 0.71 | 0.00 | 4.31 | 1.11 | 0.75 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 3.91 | 0.00 | 1.42 | 1.08 | 0.00 | 0.41 | 0.83 | 27.49 | 10.91 | 0.00 |
| NPM1 | ENSG00000181163 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 6.62 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RANBP9 | ENSG00000010017 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CSNK2B | ENSG00000204435 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TAB2 | ENSG00000055208 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 1.56 | 0.00 | 0.47 | 0.54 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PRKAR1B | ENSG00000188191 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| RSPO2 | ENSG00000147655 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 1.66 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLIN2 | ENSG00000147872 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HSPA5 | ENSG00000044574 | 1.11 | 1.02 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 1.47 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| TAB3 | ENSG00000157625 | 1.11 | 1.78 | 0.83 | 2.19 | 0.00 | 0.97 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 1.51 | 3.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.56 | 0.00 | 0.47 | 0.00 | 0.69 | 0.20 | 0.00 | 3.10 | 1.82 | 0.00 |
| SRPX2 | ENSG00000102359 | 1.11 | 0.00 | 0.10 | 0.73 | 2.86 | 0.32 | 0.00 | 0.00 | 1.03 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.20 | 0.83 | 0.89 | 1.82 | 0.00 |
| MMP23A | ENSG00000215914 | |||||||||||||||||||||||||||||||||
| MBL2 | ENSG00000165471 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.56 | 1.32 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RARA | ENSG00000131759 | 0.00 | 1.02 | 0.31 | 0.36 | 2.86 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| FGF22 | ENSG00000070388 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DEFB127 | ENSG00000088782 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DEFB118 | ENSG00000131068 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
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