Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KCNAB3 | ENSG00000170049 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RPS6KB1 | ENSG00000108443 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TUBB8P12 | ENSG00000173213 | |||||||||||||||||||||||||||||||||
| MALT1 | ENSG00000172175 | 0.00 | 2.04 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 1.69 | 1.29 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CALM3 | ENSG00000160014 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| BMP10 | ENSG00000163217 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 1.69 | 1.29 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| IGKV2D-29 | ENSG00000243264 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.13 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGLV4-69 | ENSG00000211637 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 8.11 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IGLV4-60 | ENSG00000211639 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 8.11 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGLV10-54 | ENSG00000211642 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGLV7-46 | ENSG00000211649 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGLV5-45 | ENSG00000211650 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGLV1-36 | ENSG00000211655 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGLC3 | ENSG00000211679 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 13.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TST | ENSG00000128311 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.56 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CERK | ENSG00000100422 | 0.00 | 0.76 | 0.21 | 1.46 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| IRAK2 | ENSG00000134070 | 1.11 | 1.02 | 0.31 | 1.09 | 0.00 | 0.32 | 2.70 | 0.00 | 1.03 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ATP6V1A | ENSG00000114573 | 1.11 | 2.29 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 2.58 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CSTA | ENSG00000121552 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| UCHL1 | ENSG00000154277 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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