Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ATP6V1H | ENSG00000047249 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 1.23 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| GSN | ENSG00000148180 | 0.00 | 0.51 | 0.00 | 1.09 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 1.54 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AMELX | ENSG00000125363 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RS1 | ENSG00000102104 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.00 | 0.19 | 0.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HDAC6 | ENSG00000094631 | 1.11 | 1.78 | 1.03 | 1.46 | 0.00 | 0.97 | 0.00 | 1.66 | 0.52 | 1.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.83 | 1.88 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| HSD17B10 | ENSG00000072506 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| STK26 | ENSG00000134602 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 1.13 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| KLHL17 | ENSG00000187961 | 0.00 | 1.53 | 0.21 | 0.73 | 0.00 | 0.32 | 5.41 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AKR1A1 | ENSG00000117448 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR10R3P | ENSG00000198703 | |||||||||||||||||||||||||||||||||
| RNPEP | ENSG00000176393 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CXCL12 | ENSG00000107562 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR7E5P | ENSG00000214880 | |||||||||||||||||||||||||||||||||
| AIP | ENSG00000110711 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| MTMR6 | ENSG00000139505 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 1.69 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| RIPK3 | ENSG00000129465 | 0.00 | 1.53 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 0.94 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IGHA2 | ENSG00000211890 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.65 | 10.81 | 0.55 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.29 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IGHE | ENSG00000211891 | 1.11 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TRIM72 | ENSG00000177238 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.51 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PLD2 | ENSG00000129219 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 1.29 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.86 | 1.23 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 1.25 |
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