Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KSR1 | ENSG00000141068 | 0.00 | 0.76 | 0.62 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.39 | 0.56 | 2.26 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| SIRT2 | ENSG00000068903 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PPP5C | ENSG00000011485 | 1.11 | 1.27 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.11 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PLEK | ENSG00000115956 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.97 | 2.70 | 1.10 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.32 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| GAD1 | ENSG00000128683 | 0.00 | 1.78 | 0.31 | 2.19 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 1.11 | 0.75 | 1.50 | 0.00 | 0.98 | 0.57 | 1.12 | 0.41 | 0.78 | 0.00 | 3.08 | 1.08 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RAPGEF4 | ENSG00000091428 | 0.00 | 2.29 | 0.41 | 1.82 | 0.00 | 0.97 | 0.00 | 2.21 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.88 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 3.79 | 2.17 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| INHA | ENSG00000123999 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| INPP5D | ENSG00000168918 | 0.00 | 0.51 | 0.41 | 1.09 | 2.86 | 0.97 | 0.00 | 0.55 | 1.29 | 1.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.28 | 1.51 | 4.08 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 1.29 | 5.45 | 0.54 | 0.69 | 0.20 | 0.00 | 2.88 | 0.00 | 0.00 |
| DEFB126 | ENSG00000125788 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TUBB1 | ENSG00000101162 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| PPIL2 | ENSG00000100023 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| BCR | ENSG00000186716 | 1.11 | 0.76 | 0.31 | 0.73 | 0.00 | 0.32 | 5.41 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.39 | 0.56 | 1.88 | 1.93 | 0.00 | 0.98 | 0.57 | 0.56 | 0.20 | 0.78 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| HYAL3 | ENSG00000186792 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.43 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PARP14 | ENSG00000173193 | 1.11 | 2.54 | 0.83 | 2.55 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 2.59 | 0.00 | 1.08 | 0.71 | 2.94 | 0.20 | 0.56 | 1.32 | 1.93 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 2.34 | 1.72 | 3.55 | 2.17 | 0.69 | 0.20 | 0.00 | 2.44 | 1.82 | 0.00 |
| TGFBI | ENSG00000120708 | 1.11 | 0.51 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 1.36 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| TUBB2A | ENSG00000137267 | 0.00 | 1.53 | 0.21 | 0.73 | 2.86 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TUBB2B | ENSG00000137285 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.24 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| APOM | ENSG00000204444 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR6W1P | ENSG00000179420 | |||||||||||||||||||||||||||||||||
| PDIA4 | ENSG00000155660 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.51 | 1.29 | 2.47 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
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