Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| XCR1 | ENSG00000173578 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OXTR | ENSG00000180914 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| CDCP1 | ENSG00000163814 | 2.22 | 0.51 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 1.18 | 1.39 | 0.19 | 0.64 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| BTD | ENSG00000169814 | 1.11 | 0.25 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 1.47 | 0.00 | 0.56 | 0.75 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC46A3 | ENSG00000139508 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| HCN2 | ENSG00000099822 | 0.00 | 0.25 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 1.50 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| VN1R1 | ENSG00000178201 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 2.70 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| LILRB1 | ENSG00000104972 | 2.22 | 1.53 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 1.55 | 2.19 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.83 | 3.95 | 3.00 | 0.00 | 0.49 | 1.15 | 0.00 | 0.41 | 3.13 | 0.86 | 6.64 | 1.36 | 0.00 | 0.41 | 0.00 | 2.22 | 0.00 | 0.00 |
| CACNG6 | ENSG00000130433 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LILRA1 | ENSG00000104974 | 1.11 | 1.27 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.59 | 0.83 | 3.58 | 2.36 | 0.00 | 0.74 | 1.15 | 0.00 | 0.41 | 3.13 | 0.00 | 6.40 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LILRA2 | ENSG00000239998 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 1.03 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.59 | 1.11 | 3.58 | 3.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 5.92 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| LILRB4 | ENSG00000186818 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 3.01 | 3.86 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 6.64 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CASP7 | ENSG00000165806 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CACNG7 | ENSG00000105605 | 0.00 | 1.78 | 0.21 | 0.73 | 0.00 | 1.29 | 2.70 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.94 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 2.34 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SPPL3 | ENSG00000157837 | 1.11 | 0.76 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RAB35 | ENSG00000111737 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| WNT5A | ENSG00000114251 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 1.29 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CACNA2D2 | ENSG00000007402 | 0.00 | 0.76 | 0.41 | 1.46 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 1.11 | 0.19 | 1.50 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| TUBB4B | ENSG00000188229 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| DPP7 | ENSG00000176978 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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