Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| DEFB115 | ENSG00000215547 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GDF5 | ENSG00000125965 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 1.54 | 0.54 | 0.71 | 0.74 | 0.00 | 0.56 | 1.69 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 4.98 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC25A1 | ENSG00000100075 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| AIFM3 | ENSG00000183773 | 1.11 | 0.51 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 1.54 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 0.56 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 0.00 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| MAPK1 | ENSG00000100030 | 0.00 | 0.00 | 0.10 | 4.01 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 1.79 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| JOSD1 | ENSG00000100221 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.00 | 0.43 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HDAC11 | ENSG00000163517 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| EXOG | ENSG00000157036 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.00 | 0.94 | 0.21 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TNIK | ENSG00000154310 | 0.00 | 2.04 | 0.83 | 4.01 | 2.86 | 1.94 | 0.00 | 1.10 | 0.52 | 2.99 | 0.00 | 1.36 | 0.36 | 0.00 | 0.39 | 0.28 | 1.32 | 4.72 | 0.00 | 2.21 | 1.15 | 0.00 | 0.41 | 1.56 | 0.43 | 5.21 | 1.90 | 0.00 | 0.20 | 0.00 | 3.99 | 1.82 | 0.00 |
| PAK2 | ENSG00000180370 | 0.00 | 2.04 | 0.52 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.19 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CXCL9 | ENSG00000138755 | 2.22 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CXCL10 | ENSG00000169245 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| STK32A | ENSG00000169302 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| F12 | ENSG00000131187 | 0.00 | 0.76 | 0.10 | 0.00 | 2.86 | 0.32 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 2.49 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 1.25 |
| C4B | ENSG00000224389 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SFRP1 | ENSG00000104332 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC25A32 | ENSG00000164933 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 1.13 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ERP44 | ENSG00000023318 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| INPP5E | ENSG00000148384 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 1.25 |
| OCRL | ENSG00000122126 | 1.11 | 0.25 | 0.62 | 1.82 | 0.00 | 1.61 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.83 | 1.51 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.20 | 0.00 | 3.10 | 0.00 | 0.00 |
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