Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CHST4 | ENSG00000140835 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 1.29 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| WWOX | ENSG00000186153 | 1.11 | 1.02 | 0.00 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TNFSF13 | ENSG00000161955 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC25A52 | ENSG00000141437 | 1.11 | 0.00 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CHST8 | ENSG00000124302 | 2.22 | 1.02 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.13 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.90 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| BOK | ENSG00000176720 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| XBP1 | ENSG00000100219 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CHST13 | ENSG00000180767 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC25A46 | ENSG00000164209 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.69 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| VEGFA | ENSG00000112715 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| SYNJ2 | ENSG00000078269 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.97 | 2.70 | 1.66 | 1.03 | 1.79 | 0.00 | 1.08 | 0.00 | 0.74 | 0.78 | 0.83 | 1.32 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 0.00 | 0.43 | 3.08 | 1.08 | 1.39 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC25A40 | ENSG00000075303 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IMMP2L | ENSG00000184903 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| WNT2 | ENSG00000105989 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.80 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MEST | ENSG00000106484 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| SDR16C5 | ENSG00000170786 | 1.11 | 0.51 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 1.54 | 1.36 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.45 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GBA2 | ENSG00000070610 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 0.56 | 0.94 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 1.29 | 0.47 | 0.54 | 0.00 | 0.41 | 0.83 | 1.11 | 0.00 | 1.25 |
| SLC25A51 | ENSG00000122696 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| SLC25A6 | ENSG00000169100 | 0.00 | 0.25 | 0.00 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| NYX | ENSG00000188937 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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