Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC25A20 | ENSG00000178537 | 0.00 | 0.51 | 0.10 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MGLL | ENSG00000074416 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.38 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| ST6GAL1 | ENSG00000073849 | 0.00 | 1.02 | 0.10 | 1.09 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC25A48 | ENSG00000145832 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC25A2 | ENSG00000120329 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MTCH1 | ENSG00000137409 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP5J2 | ENSG00000241468 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DAPK1 | ENSG00000196730 | 0.00 | 2.54 | 0.52 | 1.46 | 2.86 | 2.26 | 2.70 | 1.66 | 0.26 | 1.39 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 0.56 | 2.07 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 1.02 | 2.34 | 1.29 | 1.18 | 1.36 | 0.00 | 0.20 | 0.83 | 3.77 | 0.00 | 1.25 |
| COX7B | ENSG00000131174 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC25A43 | ENSG00000077713 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC25A14 | ENSG00000102078 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ABCD1 | ENSG00000101986 | 0.00 | 1.02 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 1.39 | 0.61 | 0.00 | 1.77 | 0.00 | 0.00 |
| GALNT2 | ENSG00000143641 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 1.32 | 1.29 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 1.25 |
| NUCB2 | ENSG00000070081 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRCP | ENSG00000137509 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| GLIPR1L1 | ENSG00000173401 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DCLK1 | ENSG00000133083 | 2.22 | 2.04 | 0.31 | 1.46 | 0.00 | 4.84 | 0.00 | 2.76 | 0.52 | 1.79 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 1.11 | 3.01 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 4.69 | 0.43 | 1.66 | 7.59 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| RDH11 | ENSG00000072042 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CYP46A1 | ENSG00000036530 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC25A47 | ENSG00000140107 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
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