Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC35C2 | ENSG00000080189 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC9A8 | ENSG00000197818 | 1.11 | 1.27 | 0.72 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.20 | 1.54 | 0.27 | 0.36 | 1.47 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP9A | ENSG00000054793 | 0.00 | 1.27 | 0.93 | 0.73 | 0.00 | 1.61 | 0.00 | 1.66 | 1.29 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.78 | 1.67 | 1.88 | 1.72 | 1.23 | 1.23 | 1.15 | 0.56 | 0.41 | 0.00 | 0.86 | 2.61 | 1.63 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TSPO | ENSG00000100300 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SPCS1 | ENSG00000114902 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CACNA2D3 | ENSG00000157445 | 0.00 | 1.27 | 0.72 | 0.73 | 0.00 | 3.23 | 2.70 | 1.66 | 1.29 | 0.20 | 0.00 | 0.00 | 0.36 | 1.47 | 0.39 | 1.11 | 3.20 | 0.86 | 0.00 | 0.74 | 0.57 | 1.12 | 0.41 | 5.47 | 0.00 | 13.03 | 3.52 | 0.00 | 0.41 | 0.83 | 2.44 | 1.82 | 0.00 |
| AADAC | ENSG00000114771 | 0.00 | 0.25 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.84 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ECE2 | ENSG00000145194 | 1.11 | 2.54 | 0.62 | 2.19 | 0.00 | 1.94 | 0.00 | 2.21 | 0.26 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 1.11 | 1.69 | 2.58 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 1.56 | 1.72 | 1.90 | 1.08 | 0.00 | 0.20 | 0.00 | 2.88 | 0.00 | 0.00 |
| ATP13A4 | ENSG00000127249 | 0.00 | 2.04 | 1.03 | 1.82 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 3.39 | 0.00 | 1.08 | 0.71 | 0.00 | 0.00 | 1.39 | 2.45 | 3.22 | 0.00 | 0.98 | 0.57 | 0.56 | 0.00 | 0.00 | 0.86 | 6.64 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| SLC30A9 | ENSG00000014824 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.71 | 1.47 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.66 | 0.00 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| SCD5 | ENSG00000145284 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 0.28 | 0.75 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CLCN3 | ENSG00000109572 | 0.00 | 1.53 | 0.41 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 1.00 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.56 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 1.18 | 0.81 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| SPCS3 | ENSG00000129128 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| SRD5A1 | ENSG00000145545 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HMGCR | ENSG00000113161 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.11 | 0.94 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| NDFIP1 | ENSG00000131507 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ATP10B | ENSG00000118322 | 1.11 | 1.27 | 2.07 | 2.19 | 0.00 | 2.26 | 8.11 | 2.21 | 2.58 | 2.99 | 1.54 | 0.54 | 0.36 | 0.74 | 1.18 | 2.22 | 4.52 | 5.36 | 0.00 | 0.74 | 1.15 | 0.00 | 1.22 | 0.00 | 0.86 | 5.69 | 3.25 | 0.00 | 0.20 | 0.83 | 2.88 | 0.00 | 0.00 |
| ATP6V0E1 | ENSG00000113732 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC35B3 | ENSG00000124786 | 1.11 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MBOAT1 | ENSG00000172197 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.56 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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