Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ATP8B1 | ENSG00000081923 | 0.00 | 3.05 | 0.41 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 1.29 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.72 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 2.34 | 0.43 | 1.42 | 1.63 | 0.00 | 0.00 | 0.83 | 2.88 | 0.00 | 0.00 |
| FLVCR1 | ENSG00000162769 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 0.00 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OLFM4 | ENSG00000102837 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 0.56 | 3.20 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| ATP6V0A1 | ENSG00000033627 | 1.11 | 2.80 | 0.21 | 1.09 | 2.86 | 0.32 | 2.70 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 1.39 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PXDN | ENSG00000130508 | 1.11 | 3.56 | 0.41 | 1.46 | 0.00 | 3.87 | 2.70 | 4.97 | 0.77 | 1.79 | 0.00 | 1.36 | 0.36 | 0.00 | 0.39 | 1.94 | 3.77 | 4.29 | 1.23 | 1.47 | 2.30 | 0.00 | 0.00 | 3.91 | 0.00 | 4.03 | 5.96 | 0.00 | 0.00 | 0.00 | 6.65 | 3.64 | 0.00 |
| LTK | ENSG00000062524 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 1.39 | 1.32 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| CXCR2 | ENSG00000180871 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 1.13 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SSC5D | ENSG00000179954 | 0.00 | 0.00 | 0.52 | 0.73 | 0.00 | 4.52 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.83 | 0.00 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.69 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| WNT6 | ENSG00000115596 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CDK5 | ENSG00000164885 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| HTR2B | ENSG00000135914 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| IL17RC | ENSG00000163702 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HRH1 | ENSG00000196639 | 0.00 | 2.04 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 0.38 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CCRL2 | ENSG00000121797 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GLB1 | ENSG00000170266 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 1.36 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.00 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC6A20 | ENSG00000163817 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| NUP210 | ENSG00000132182 | 1.11 | 3.82 | 0.41 | 0.73 | 2.86 | 0.97 | 2.70 | 2.21 | 0.77 | 1.20 | 0.00 | 0.27 | 1.07 | 0.74 | 0.39 | 0.56 | 3.58 | 1.72 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 6.87 | 1.36 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 1.25 |
| FZD2 | ENSG00000180340 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 1.51 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| PLCD3 | ENSG00000161714 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.32 | 2.70 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| ABCA12 | ENSG00000144452 | 4.44 | 4.58 | 1.34 | 4.38 | 0.00 | 4.52 | 2.70 | 5.52 | 0.00 | 3.59 | 1.54 | 1.63 | 1.78 | 0.74 | 0.39 | 4.17 | 6.21 | 3.00 | 0.00 | 1.96 | 1.15 | 1.12 | 0.81 | 3.91 | 0.43 | 12.80 | 6.50 | 0.00 | 0.20 | 0.00 | 5.54 | 5.45 | 1.25 |
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