Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| MGST3 | ENSG00000143198 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC9C2 | ENSG00000162753 | 0.00 | 1.78 | 0.41 | 0.36 | 0.00 | 1.29 | 2.70 | 2.21 | 0.77 | 1.59 | 1.54 | 0.27 | 0.71 | 0.00 | 0.78 | 1.39 | 3.20 | 2.79 | 0.00 | 0.74 | 0.57 | 0.00 | 0.81 | 0.78 | 2.16 | 10.43 | 2.71 | 0.00 | 0.00 | 0.00 | 2.44 | 1.82 | 0.00 |
| SLC35F3 | ENSG00000183780 | 2.22 | 1.53 | 0.31 | 0.73 | 0.00 | 1.61 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.74 | 0.59 | 0.00 | 1.88 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 4.03 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| CISD1 | ENSG00000122873 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CYP26C1 | ENSG00000187553 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC35C1 | ENSG00000181830 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DHCR7 | ENSG00000172893 | 1.11 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC35F2 | ENSG00000110660 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LPCAT3 | ENSG00000111684 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 0.00 | 0.43 | 0.00 | 0.49 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| MGST1 | ENSG00000008394 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PDE3A | ENSG00000172572 | 1.11 | 2.80 | 0.83 | 2.92 | 0.00 | 1.94 | 10.81 | 3.31 | 0.52 | 3.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 2.50 | 3.77 | 5.58 | 0.00 | 0.98 | 1.72 | 0.00 | 0.00 | 1.56 | 0.86 | 5.45 | 2.98 | 0.69 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| ITPR2 | ENSG00000123104 | 2.22 | 5.85 | 0.93 | 2.19 | 2.86 | 0.65 | 2.70 | 0.55 | 1.03 | 3.98 | 0.00 | 1.90 | 1.78 | 0.00 | 0.59 | 1.94 | 5.65 | 5.15 | 0.00 | 1.23 | 0.57 | 0.00 | 1.43 | 1.56 | 2.59 | 3.55 | 1.90 | 0.00 | 1.02 | 0.83 | 5.54 | 0.00 | 0.00 |
| RDH16 | ENSG00000139547 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 1.54 | 0.54 | 0.71 | 0.00 | 0.00 | 0.56 | 0.38 | 0.86 | 2.47 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| USP30 | ENSG00000135093 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.19 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| EBPL | ENSG00000123179 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| BCL2L10 | ENSG00000137875 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ATP6V0C | ENSG00000185883 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ERN2 | ENSG00000134398 | 0.00 | 1.78 | 0.72 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.77 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.94 | 2.45 | 2.58 | 0.00 | 1.72 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 5.92 | 1.08 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| SPNS1 | ENSG00000169682 | 0.00 | 1.27 | 0.31 | 1.09 | 2.86 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| CKLF | ENSG00000217555 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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