Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BCL2L13 | ENSG00000099968 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| HHATL | ENSG00000010282 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CYP8B1 | ENSG00000180432 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.11 | 0.56 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| P4HTM | ENSG00000178467 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.74 | 0.00 | 1.12 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC9C1 | ENSG00000172139 | 0.00 | 2.29 | 0.83 | 2.55 | 2.86 | 0.65 | 0.00 | 1.66 | 1.55 | 1.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.59 | 2.78 | 2.07 | 3.65 | 0.00 | 1.72 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 7.11 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| ATP2C1 | ENSG00000017260 | 0.00 | 1.02 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 3.31 | 0.26 | 1.59 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.56 | 1.32 | 2.36 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CHST2 | ENSG00000175040 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 1.94 | 0.00 | 0.00 | 1.03 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.83 | 1.13 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 1.39 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| TMPRSS11F | ENSG00000198092 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.59 | 0.28 | 1.88 | 1.72 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.55 | 1.90 | 0.00 | 0.20 | 0.00 | 0.22 | 1.82 | 0.00 |
| UGT2B15 | ENSG00000196620 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.66 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 1.88 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 8.29 | 0.00 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| UGT2B10 | ENSG00000109181 | 0.00 | 0.76 | 0.41 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.59 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 1.39 | 1.51 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 5.92 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| UGT2B11 | ENSG00000213759 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.28 | 3.58 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 4.98 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| UGT2B7 | ENSG00000171234 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 5.41 | 0.00 | 0.52 | 1.20 | 1.54 | 0.54 | 0.36 | 0.00 | 0.39 | 0.83 | 1.51 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 3.79 | 0.54 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| UGT2B28 | ENSG00000135226 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 1.55 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 3.58 | 2.58 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 7.35 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CYP4V2 | ENSG00000145476 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 2.07 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| GPX8 | ENSG00000164294 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| BTNL8 | ENSG00000113303 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 1.00 | 1.54 | 0.81 | 0.36 | 1.47 | 0.59 | 0.28 | 1.51 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 4.74 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TAP2 | ENSG00000204267 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| BAK1 | ENSG00000030110 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNK16 | ENSG00000095981 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.80 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| STEAP1 | ENSG00000164647 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.00 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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