Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TASP1 | ENSG00000089123 | 0.00 | 0.51 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 2.15 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| GADL1 | ENSG00000144644 | 1.11 | 0.76 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 1.13 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| USP4 | ENSG00000114316 | 0.00 | 2.54 | 0.10 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 1.11 | 0.94 | 0.86 | 1.23 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| WDR1 | ENSG00000071127 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| METAP1 | ENSG00000164024 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 1.23 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| TDO2 | ENSG00000151790 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.51 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 1.36 | 0.00 | 0.20 | 0.83 | 0.00 | 0.00 | 0.00 |
| AADAT | ENSG00000109576 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ENC1 | ENSG00000171617 | 2.22 | 0.25 | 0.31 | 0.36 | 2.86 | 0.65 | 2.70 | 0.00 | 1.29 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 1.23 | 1.15 | 0.56 | 0.20 | 0.78 | 0.43 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| RIOK2 | ENSG00000058729 | 0.00 | 2.54 | 0.31 | 0.36 | 2.86 | 0.00 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 0.00 | 0.00 | 0.41 | 0.83 | 0.67 | 0.00 | 0.00 |
| HMMR | ENSG00000072571 | 1.11 | 0.00 | 0.21 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.83 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 0.71 | 0.54 | 1.39 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NSD1 | ENSG00000165671 | 3.33 | 4.83 | 0.72 | 5.11 | 0.00 | 2.90 | 0.00 | 3.87 | 0.77 | 11.35 | 0.00 | 1.63 | 1.42 | 0.00 | 0.20 | 1.94 | 3.20 | 5.15 | 1.23 | 1.47 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 4.03 | 2.44 | 0.00 | 0.61 | 0.83 | 10.64 | 1.82 | 1.25 |
| SRPK1 | ENSG00000096063 | 1.11 | 0.51 | 0.41 | 0.36 | 0.00 | 1.29 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GLO1 | ENSG00000124767 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HSPB1 | ENSG00000106211 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| NAMPT | ENSG00000105835 | 0.00 | 0.76 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| AKR1B10 | ENSG00000198074 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.69 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| AKR1B15 | ENSG00000227471 | 1.11 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.28 | 2.07 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| ASH2L | ENSG00000129691 | 0.00 | 0.00 | 0.52 | 0.73 | 2.86 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 1.07 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| JAK2 | ENSG00000096968 | 1.11 | 1.27 | 0.41 | 1.82 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.83 | 2.26 | 2.58 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.81 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| PLAA | ENSG00000137055 | 0.00 | 0.51 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 1.39 | 1.54 | 0.27 | 0.00 | 0.74 | 0.20 | 0.28 | 0.56 | 0.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.81 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
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