Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| MAP3K7 | ENSG00000135341 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.83 | 1.51 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| EPM2A | ENSG00000112425 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LRRC17 | ENSG00000128606 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 1.66 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| BRAF | ENSG00000157764 | 1.11 | 2.80 | 0.41 | 0.73 | 2.86 | 5.48 | 2.70 | 1.10 | 1.55 | 1.59 | 0.00 | 0.27 | 1.42 | 0.00 | 0.39 | 0.00 | 6.21 | 3.00 | 1.23 | 0.49 | 1.15 | 0.56 | 1.22 | 0.78 | 0.00 | 51.90 | 1.90 | 0.00 | 59.06 | 0.00 | 1.55 | 0.00 | 0.00 |
| CA2 | ENSG00000104267 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.61 | 0.78 | 0.86 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| ATP6V0D2 | ENSG00000147614 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| FBP2 | ENSG00000130957 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.97 | 5.41 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 1.23 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| C9orf3 | ENSG00000148120 | 1.11 | 1.53 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.59 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 0.00 | 1.69 | 1.07 | 0.00 | 0.00 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP6V1G1 | ENSG00000136888 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HDAC8 | ENSG00000147099 | 0.00 | 0.51 | 0.52 | 0.73 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| COL16A1 | ENSG00000084636 | 0.00 | 1.53 | 0.52 | 2.55 | 0.00 | 1.61 | 2.70 | 1.66 | 0.52 | 1.59 | 1.54 | 0.54 | 0.71 | 0.74 | 0.20 | 2.50 | 2.07 | 1.93 | 1.23 | 1.23 | 0.57 | 0.56 | 0.61 | 0.00 | 0.86 | 2.37 | 1.63 | 0.00 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| MYSM1 | ENSG00000162601 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 0.28 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| WARS2 | ENSG00000116874 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| S100A13 | ENSG00000189171 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| USP21 | ENSG00000143258 | 1.11 | 1.78 | 0.21 | 0.73 | 2.86 | 0.65 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| YOD1 | ENSG00000180667 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| LGALS8 | ENSG00000116977 | 1.11 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR2L8 | ENSG00000196936 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.00 | 2.70 | 1.66 | 0.77 | 0.80 | 0.00 | 1.36 | 0.71 | 0.00 | 0.20 | 1.11 | 4.90 | 3.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 3.32 | 1.90 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRAP1 | ENSG00000165828 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR5D13 | ENSG00000198877 | 1.11 | 0.76 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 3.87 | 2.06 | 2.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 4.33 | 3.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 3.55 | 3.25 | 0.00 | 0.41 | 0.00 | 1.55 | 0.00 | 0.00 |
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