Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC38A6 | ENSG00000139974 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PAM | ENSG00000145730 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.77 | 1.20 | 0.00 | 0.54 | 1.07 | 0.00 | 0.20 | 0.83 | 0.94 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 4.03 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD53 | ENSG00000143119 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EXTL2 | ENSG00000162694 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 1.47 | 0.20 | 0.00 | 0.75 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR135 | ENSG00000181619 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TMPRSS13 | ENSG00000137747 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| IL10RA | ENSG00000110324 | 0.00 | 1.53 | 0.21 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.83 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| AMICA1 | ENSG00000160593 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TGFBR3 | ENSG00000069702 | 2.22 | 1.78 | 0.52 | 0.36 | 0.00 | 0.97 | 5.41 | 1.10 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 1.47 | 0.20 | 0.00 | 2.64 | 1.72 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 1.56 | 0.43 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| CD3D | ENSG00000167286 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD3G | ENSG00000160654 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC7A2 | ENSG00000003989 | 0.00 | 1.27 | 0.00 | 0.36 | 0.00 | 0.65 | 8.11 | 1.10 | 0.26 | 0.20 | 0.00 | 0.81 | 1.07 | 0.00 | 0.20 | 0.28 | 0.56 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HSPG2 | ENSG00000142798 | 4.44 | 5.09 | 1.03 | 3.28 | 0.00 | 1.29 | 2.70 | 3.87 | 3.87 | 3.78 | 3.08 | 0.81 | 1.42 | 2.21 | 1.76 | 2.50 | 4.52 | 4.51 | 0.00 | 2.94 | 0.57 | 1.12 | 1.02 | 2.34 | 0.86 | 5.92 | 2.71 | 0.00 | 0.20 | 1.65 | 7.32 | 1.82 | 1.25 |
| SLC44A3 | ENSG00000143036 | 1.11 | 0.76 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 1.39 | 1.32 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD3E | ENSG00000198851 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.83 | 0.44 | 1.82 | 0.00 |
| TLR5 | ENSG00000187554 | 0.00 | 2.29 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 0.28 | 0.94 | 1.29 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.00 | 0.86 | 4.74 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| SLC38A9 | ENSG00000177058 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| MOXD1 | ENSG00000079931 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 2.21 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 2.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 1.56 | 0.86 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PLBD2 | ENSG00000151176 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 1.13 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CDH13 | ENSG00000140945 | 0.00 | 2.54 | 0.41 | 1.46 | 0.00 | 1.29 | 2.70 | 1.10 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.83 | 2.26 | 3.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 2.34 | 0.00 | 4.50 | 1.63 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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