Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CFD | ENSG00000197766 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAP2K2 | ENSG00000126934 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KLK10 | ENSG00000129451 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RASGRP3 | ENSG00000152689 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 1.61 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 1.32 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 3.55 | 1.63 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP6V1B1 | ENSG00000116039 | 0.00 | 2.04 | 0.31 | 0.36 | 0.00 | 1.61 | 0.00 | 0.55 | 0.26 | 0.60 | 1.54 | 0.54 | 0.36 | 0.74 | 0.00 | 0.28 | 0.19 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| IGKV3-11 | ENSG00000241351 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGKV4-1 | ENSG00000211598 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 13.51 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGKV1-5 | ENSG00000243466 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 16.22 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 2.26 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGKV3-15 | ENSG00000244437 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGKV3-20 | ENSG00000239951 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 8.11 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGKV2-30 | ENSG00000243238 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGKV1-39 | ENSG00000242371 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGKV1D-16 | ENSG00000241244 | 0.00 | 0.76 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 2.79 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FBLN7 | ENSG00000144152 | 1.11 | 1.27 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 0.54 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| CASP10 | ENSG00000003400 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PDYN | ENSG00000101327 | 1.11 | 0.25 | 0.31 | 0.36 | 0.00 | 1.94 | 0.00 | 0.55 | 1.03 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 2.07 | 4.29 | 1.23 | 0.98 | 0.57 | 0.00 | 0.61 | 2.34 | 0.00 | 3.32 | 1.36 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SNAP25 | ENSG00000132639 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 1.03 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PLCG1 | ENSG00000124181 | 3.33 | 2.29 | 0.72 | 0.36 | 2.86 | 0.65 | 2.70 | 3.31 | 1.29 | 1.59 | 0.00 | 0.00 | 0.36 | 0.74 | 0.78 | 1.67 | 1.32 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 1.29 | 1.42 | 1.36 | 0.00 | 0.20 | 0.83 | 2.44 | 0.00 | 0.00 |
| LIPI | ENSG00000188992 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.39 | 0.00 | 0.81 | 0.71 | 0.00 | 0.78 | 1.11 | 2.26 | 2.15 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 6.40 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| GGTLC3 | ENSG00000274252 |
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