Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PLK4 | ENSG00000142731 | 0.00 | 2.29 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 1.54 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 2.07 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| PDE6A | ENSG00000132915 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 1.39 | 2.07 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.79 | 1.36 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| BLK | ENSG00000136573 | 0.00 | 0.51 | 0.41 | 0.36 | 2.86 | 0.00 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 2.07 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 4.03 | 1.63 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PTP4A3 | ENSG00000184489 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 3.64 | 0.00 |
| RAB9A | ENSG00000123595 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IRAK1 | ENSG00000184216 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 1.11 | 0.56 | 2.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GALE | ENSG00000117308 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GLUL | ENSG00000135821 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 1.29 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ATP6V1G3 | ENSG00000151418 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.00 | 0.86 | 0.00 | 0.25 | 0.00 | 1.12 | 0.00 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PTPN7 | ENSG00000143851 | 1.11 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PIK3C2B | ENSG00000133056 | 0.00 | 3.05 | 0.93 | 2.19 | 0.00 | 1.29 | 0.00 | 1.66 | 1.03 | 1.20 | 1.54 | 0.00 | 1.42 | 0.00 | 0.20 | 1.94 | 3.20 | 3.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 3.79 | 1.90 | 0.00 | 0.00 | 0.83 | 3.10 | 0.00 | 0.00 |
| GAD2 | ENSG00000136750 | 0.00 | 1.53 | 0.52 | 0.00 | 0.00 | 2.26 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.83 | 3.39 | 4.08 | 0.00 | 0.98 | 0.57 | 0.00 | 1.63 | 0.78 | 0.43 | 2.37 | 0.81 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| VCL | ENSG00000035403 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 2.76 | 0.52 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.11 | 1.13 | 1.29 | 0.00 | 1.72 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| PTEN | ENSG00000171862 | 0.00 | 3.31 | 5.17 | 6.57 | 0.00 | 3.87 | 2.70 | 2.76 | 32.47 | 2.19 | 9.23 | 3.79 | 2.85 | 0.00 | 4.31 | 1.94 | 1.13 | 10.94 | 2.47 | 1.72 | 0.00 | 0.00 | 3.67 | 3.91 | 2.59 | 9.48 | 4.34 | 0.00 | 0.41 | 0.00 | 60.53 | 16.36 | 0.00 |
| FKBP2 | ENSG00000173486 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SSH3 | ENSG00000172830 | 0.00 | 3.56 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.56 | 1.13 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.86 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| PPP1CA | ENSG00000172531 | 2.22 | 1.53 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MMP10 | ENSG00000166670 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.78 | 0.56 | 1.13 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CACNB3 | ENSG00000167535 | 1.11 | 0.76 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.19 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| APPL2 | ENSG00000136044 | 0.00 | 1.27 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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