Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KCNF1 | ENSG00000162975 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.39 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC30A3 | ENSG00000115194 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 0.56 | 0.38 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CACNB4 | ENSG00000182389 | 0.00 | 0.76 | 0.00 | 1.46 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.11 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| KCNH7 | ENSG00000184611 | 4.44 | 2.29 | 0.72 | 0.73 | 0.00 | 2.90 | 0.00 | 1.10 | 0.77 | 3.19 | 0.00 | 2.44 | 0.71 | 0.00 | 0.20 | 0.83 | 4.33 | 9.01 | 0.00 | 1.96 | 0.57 | 0.00 | 0.61 | 3.13 | 0.43 | 9.48 | 2.71 | 0.00 | 0.20 | 0.00 | 3.33 | 1.82 | 0.00 |
| SLC4A3 | ENSG00000114923 | 0.00 | 1.02 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.59 | 0.00 | 0.81 | 0.00 | 0.74 | 0.39 | 2.22 | 3.01 | 3.00 | 1.23 | 1.23 | 0.57 | 0.00 | 0.00 | 3.13 | 0.00 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| KCNJ13 | ENSG00000115474 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTGIS | ENSG00000124212 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.43 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HMOX1 | ENSG00000100292 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TRPC1 | ENSG00000144935 | 0.00 | 1.27 | 0.21 | 1.09 | 0.00 | 0.65 | 2.70 | 1.10 | 0.52 | 1.79 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 1.69 | 2.58 | 1.23 | 1.23 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 3.64 | 0.00 |
| ATP11B | ENSG00000058063 | 1.11 | 1.53 | 0.31 | 1.82 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.80 | 1.54 | 0.27 | 0.36 | 0.74 | 0.00 | 0.83 | 1.13 | 3.00 | 0.00 | 1.23 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| CNGA1 | ENSG00000198515 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.28 | 1.32 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.79 | 0.81 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC9B1 | ENSG00000164037 | 0.00 | 1.78 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC27A6 | ENSG00000113396 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 2.70 | 1.10 | 1.29 | 1.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.83 | 3.95 | 2.79 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 1.56 | 0.43 | 7.11 | 1.63 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 1.25 |
| CATSPER3 | ENSG00000152705 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.83 | 0.56 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC4A9 | ENSG00000113073 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 1.29 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 1.07 | 1.23 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 1.66 | 0.27 | 0.69 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| SLC17A2 | ENSG00000112337 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 1.69 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC35A1 | ENSG00000164414 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC26A7 | ENSG00000147606 | 0.00 | 1.53 | 0.62 | 0.73 | 2.86 | 0.97 | 2.70 | 1.66 | 0.26 | 1.79 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 1.67 | 4.14 | 4.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 3.55 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TRPM6 | ENSG00000119121 | 1.11 | 3.82 | 1.45 | 2.92 | 2.86 | 1.94 | 8.11 | 1.66 | 1.55 | 2.19 | 0.00 | 1.63 | 0.71 | 0.00 | 0.98 | 2.22 | 5.27 | 4.94 | 0.00 | 0.74 | 1.72 | 0.00 | 0.81 | 1.56 | 2.16 | 8.29 | 2.17 | 0.00 | 0.00 | 0.00 | 3.55 | 1.82 | 1.25 |
| MAST2 | ENSG00000086015 | 0.00 | 2.04 | 0.52 | 0.73 | 0.00 | 1.29 | 0.00 | 2.76 | 1.29 | 1.39 | 0.00 | 0.81 | 0.71 | 0.74 | 0.59 | 1.11 | 1.32 | 3.00 | 0.00 | 2.94 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
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