Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KCNN3 | ENSG00000143603 | 1.11 | 1.27 | 0.41 | 0.73 | 0.00 | 1.29 | 0.00 | 1.10 | 1.03 | 0.00 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 1.11 | 1.88 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 4.03 | 0.54 | 0.00 | 0.41 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNJ9 | ENSG00000162728 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| KCNJ11 | ENSG00000187486 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CATSPER1 | ENSG00000175294 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 1.61 | 0.00 | 0.55 | 0.00 | 1.39 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 1.39 | 1.13 | 0.86 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 2.34 | 1.29 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 3.77 | 3.64 | 0.00 |
| KCNJ5 | ENSG00000120457 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| KCNJ8 | ENSG00000121361 | 0.00 | 1.27 | 0.21 | 1.09 | 0.00 | 0.65 | 5.41 | 2.21 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.56 | 1.88 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.08 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| AQP6 | ENSG00000086159 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.95 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| ABCD4 | ENSG00000119688 | 1.11 | 0.25 | 0.10 | 0.73 | 0.00 | 0.65 | 5.41 | 0.55 | 0.52 | 0.60 | 0.00 | 1.36 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.83 | 0.44 | 0.00 | 0.00 |
| ATXN3 | ENSG00000066427 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC24A1 | ENSG00000074621 | 0.00 | 2.29 | 0.21 | 2.19 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| RHBDL1 | ENSG00000103269 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| OTOA | ENSG00000155719 | 0.00 | 0.25 | 0.93 | 1.46 | 0.00 | 1.29 | 0.00 | 0.00 | 2.06 | 1.00 | 0.00 | 0.81 | 0.00 | 1.47 | 0.39 | 0.56 | 2.26 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 3.32 | 1.36 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC9A5 | ENSG00000135740 | 0.00 | 1.53 | 0.31 | 1.46 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.13 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 1.90 | 1.36 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| P2RX5 | ENSG00000083454 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.69 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC39A11 | ENSG00000133195 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.21 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC38A10 | ENSG00000157637 | 0.00 | 1.78 | 0.62 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 0.75 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.42 | 1.63 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| MADCAM1 | ENSG00000099866 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC39A3 | ENSG00000141873 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCNN1 | ENSG00000105642 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 1.56 | 0.43 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| DMPK | ENSG00000104936 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 1.07 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
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