Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| COL5A1 | ENSG00000130635 | 3.33 | 2.80 | 0.83 | 2.19 | 0.00 | 4.19 | 0.00 | 3.31 | 1.29 | 2.59 | 0.00 | 0.81 | 1.42 | 0.74 | 0.39 | 3.06 | 4.90 | 4.51 | 0.00 | 1.47 | 2.87 | 0.00 | 1.22 | 3.13 | 0.00 | 13.98 | 3.79 | 0.00 | 0.61 | 0.00 | 5.32 | 0.00 | 1.25 |
| PAEP | ENSG00000122133 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LCN9 | ENSG00000148386 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LCN8 | ENSG00000204001 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SIGMAR1 | ENSG00000147955 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SMPD3 | ENSG00000103056 | 0.00 | 1.27 | 0.10 | 0.00 | 2.86 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 2.13 | 0.27 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| PTPN2 | ENSG00000175354 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 2.70 | 1.10 | 0.26 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR10C1 | ENSG00000206474 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 1.29 | 2.70 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 1.69 | 1.29 | 0.00 | 1.72 | 0.57 | 0.00 | 0.41 | 0.78 | 0.86 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CYP4A11 | ENSG00000187048 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 1.99 | 0.00 | 1.08 | 1.07 | 0.00 | 0.20 | 0.56 | 1.13 | 0.21 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 1.29 | 6.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| VAMP1 | ENSG00000139190 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| FKBP11 | ENSG00000134285 | 1.11 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DIO2 | ENSG00000211448 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 2.21 | 0.26 | 0.80 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 0.28 | 2.45 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CYP4F2 | ENSG00000186115 | 0.00 | 1.53 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 1.29 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 1.88 | 1.72 | 1.23 | 1.23 | 0.00 | 0.56 | 0.20 | 0.00 | 0.86 | 2.61 | 2.17 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| STIM2 | ENSG00000109689 | 1.11 | 0.51 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| ATP6AP2 | ENSG00000182220 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OPN1MW2 | ENSG00000166160 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DIO1 | ENSG00000211452 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| APH1A | ENSG00000117362 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADCY10 | ENSG00000143199 | 0.00 | 2.29 | 0.72 | 1.09 | 0.00 | 0.97 | 0.00 | 2.21 | 0.52 | 0.80 | 0.00 | 0.81 | 1.42 | 0.00 | 0.39 | 1.11 | 3.77 | 3.65 | 0.00 | 1.47 | 0.57 | 0.56 | 0.00 | 0.00 | 0.43 | 7.82 | 2.44 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| SLC35G1 | ENSG00000176273 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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