Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| WISP3 | ENSG00000112761 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SMPDL3A | ENSG00000172594 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGFBP3 | ENSG00000146674 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| GPIHBP1 | ENSG00000277494 | |||||||||||||||||||||||||||||||||
| PON1 | ENSG00000005421 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.56 | 1.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PCOLCE | ENSG00000106333 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.00 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ANGPT2 | ENSG00000091879 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.13 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 0.00 |
| CTSB | ENSG00000164733 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 0.56 | 0.38 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| PDGFRL | ENSG00000104213 | 0.00 | 0.00 | 0.10 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.75 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| STC1 | ENSG00000159167 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CRH | ENSG00000147571 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PI15 | ENSG00000137558 | 1.11 | 0.76 | 0.31 | 0.00 | 2.86 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.56 | 1.32 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 1.90 | 0.00 | 0.00 | 1.65 | 0.22 | 0.00 | 0.00 |
| OC90 | ENSG00000253117 | |||||||||||||||||||||||||||||||||
| INSL4 | ENSG00000120211 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RLN1 | ENSG00000107018 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| CER1 | ENSG00000147869 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 4.03 | 0.54 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| ASPN | ENSG00000106819 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ORM2 | ENSG00000228278 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OLFML2A | ENSG00000185585 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.83 | 0.75 | 1.72 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| ANGPTL2 | ENSG00000136859 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.83 | 1.77 | 0.00 | 0.00 |
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