Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| COL5A3 | ENSG00000080573 | 0.00 | 2.80 | 1.03 | 1.46 | 0.00 | 2.58 | 2.70 | 0.55 | 1.03 | 1.99 | 1.54 | 2.17 | 1.07 | 0.74 | 0.00 | 1.67 | 3.01 | 5.15 | 0.00 | 2.94 | 1.15 | 0.56 | 0.61 | 1.56 | 1.29 | 12.32 | 3.25 | 0.69 | 1.02 | 0.00 | 3.33 | 0.00 | 0.00 |
| DAND5 | ENSG00000179284 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COMP | ENSG00000105664 | 0.00 | 2.04 | 0.62 | 1.09 | 0.00 | 0.32 | 2.70 | 1.10 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GAPDHS | ENSG00000105679 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.28 | 0.94 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PSG1 | ENSG00000231924 | 0.00 | 1.53 | 0.52 | 0.73 | 0.00 | 2.26 | 0.00 | 1.66 | 1.29 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 2.07 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 1.56 | 1.72 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| CEACAM16 | ENSG00000213892 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CGB2 | ENSG00000104818 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR4C45 | ENSG00000260811 | |||||||||||||||||||||||||||||||||
| A1BG | ENSG00000121410 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 0.19 | 0.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| LTBP1 | ENSG00000049323 | 1.11 | 4.58 | 1.03 | 0.73 | 0.00 | 0.65 | 0.00 | 3.87 | 0.52 | 3.98 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 1.94 | 8.85 | 4.94 | 0.00 | 0.74 | 0.57 | 0.56 | 0.61 | 1.56 | 0.00 | 7.35 | 1.63 | 0.00 | 0.61 | 0.83 | 2.00 | 0.00 | 0.00 |
| COL3A1 | ENSG00000168542 | 0.00 | 2.80 | 0.62 | 1.82 | 0.00 | 2.90 | 5.41 | 1.66 | 1.55 | 2.39 | 1.54 | 0.81 | 0.00 | 0.00 | 0.59 | 1.94 | 8.85 | 6.22 | 0.00 | 1.96 | 1.15 | 0.00 | 0.20 | 1.56 | 0.00 | 13.27 | 1.90 | 0.69 | 0.41 | 1.65 | 2.66 | 1.82 | 0.00 |
| ANGPT4 | ENSG00000101280 | 0.00 | 1.27 | 0.72 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 1.29 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 1.32 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| CPXM1 | ENSG00000088882 | 0.00 | 0.76 | 0.83 | 0.73 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 0.80 | 1.54 | 0.81 | 1.07 | 0.74 | 0.00 | 0.28 | 2.07 | 1.29 | 1.23 | 0.98 | 0.00 | 0.56 | 0.41 | 2.34 | 0.00 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| CST7 | ENSG00000077984 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MATN4 | ENSG00000124159 | 0.00 | 1.78 | 0.41 | 0.00 | 0.00 | 1.29 | 0.00 | 1.66 | 1.03 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 1.11 | 1.51 | 1.93 | 2.47 | 0.74 | 0.57 | 0.56 | 0.20 | 1.56 | 0.43 | 3.55 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 1.25 |
| MMP9 | ENSG00000100985 | 1.11 | 1.78 | 0.41 | 0.36 | 0.00 | 1.94 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 2.36 | 0.00 | 1.23 | 0.00 | 0.00 | 0.81 | 0.78 | 0.86 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| TFF2 | ENSG00000160181 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| COL6A1 | ENSG00000142156 | 0.00 | 0.25 | 0.62 | 1.09 | 2.86 | 0.65 | 2.70 | 2.76 | 1.03 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.69 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 1.42 | 0.81 | 0.00 | 0.00 | 0.83 | 2.88 | 0.00 | 0.00 |
| LIF | ENSG00000128342 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NAGA | ENSG00000198951 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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