Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CFHR1 | ENSG00000244414 | 0.00 | 0.25 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.32 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CFHR5 | ENSG00000134389 | 0.00 | 1.27 | 0.21 | 2.19 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 2.45 | 3.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.41 | 3.91 | 0.00 | 8.29 | 1.90 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| FMOD | ENSG00000122176 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.00 | 0.86 | 2.13 | 1.90 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| LAMB3 | ENSG00000196878 | 0.00 | 2.54 | 0.83 | 1.82 | 0.00 | 0.97 | 0.00 | 1.10 | 1.55 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.67 | 3.01 | 1.72 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 4.98 | 1.36 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ITIH5 | ENSG00000123243 | 1.11 | 1.02 | 0.52 | 1.09 | 0.00 | 1.29 | 0.00 | 2.76 | 1.03 | 1.00 | 0.00 | 1.36 | 0.36 | 2.21 | 0.00 | 1.94 | 4.33 | 4.08 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 4.27 | 3.25 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ITIH2 | ENSG00000151655 | 1.11 | 2.80 | 0.10 | 1.46 | 0.00 | 2.90 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 0.56 | 3.77 | 3.43 | 0.00 | 0.74 | 0.00 | 0.00 | 1.22 | 0.00 | 0.00 | 4.27 | 1.08 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| CCDC3 | ENSG00000151468 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| GABRQ | ENSG00000268089 | |||||||||||||||||||||||||||||||||
| LOXL4 | ENSG00000138131 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.83 | 0.38 | 0.86 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PKD1L3 | ENSG00000277481 | |||||||||||||||||||||||||||||||||
| PNLIPRP3 | ENSG00000203837 | 1.11 | 1.02 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 2.21 | 0.00 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 2.07 | 4.51 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.90 | 1.90 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PNLIPRP2 | ENSG00000266200 | |||||||||||||||||||||||||||||||||
| MUC6 | ENSG00000184956 | 1.11 | 2.80 | 0.93 | 1.09 | 2.86 | 2.26 | 8.11 | 4.42 | 0.26 | 1.99 | 1.54 | 0.54 | 1.07 | 0.00 | 0.39 | 2.22 | 2.82 | 5.36 | 0.00 | 0.49 | 1.72 | 0.00 | 0.61 | 1.56 | 1.29 | 3.79 | 6.50 | 0.69 | 0.41 | 0.00 | 3.55 | 0.00 | 0.00 |
| MUC2 | ENSG00000198788 | 0.00 | 1.78 | 1.14 | 1.82 | 2.86 | 1.29 | 0.00 | 1.10 | 1.55 | 1.39 | 1.54 | 1.90 | 1.78 | 0.00 | 1.18 | 3.33 | 4.52 | 4.29 | 1.23 | 0.25 | 1.15 | 0.00 | 1.02 | 0.78 | 1.29 | 7.58 | 1.63 | 0.00 | 0.20 | 0.00 | 3.33 | 1.82 | 1.25 |
| MUC5AC | ENSG00000215182 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 1.11 | 2.26 | 2.36 | 0.00 | 0.00 | 1.72 | 0.56 | 0.00 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 1.25 |
| FSHB | ENSG00000131808 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADAMTS15 | ENSG00000166106 | 0.00 | 2.54 | 0.10 | 0.73 | 0.00 | 1.61 | 2.70 | 0.55 | 0.26 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.78 | 0.28 | 2.07 | 1.93 | 0.00 | 0.74 | 1.72 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 1.08 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| PRB2 | ENSG00000121335 | 1.11 | 1.27 | 0.62 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 2.26 | 3.65 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 8.06 | 0.54 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| COL2A1 | ENSG00000139219 | 0.00 | 3.31 | 0.62 | 1.46 | 0.00 | 1.94 | 0.00 | 1.10 | 1.55 | 1.00 | 1.54 | 1.08 | 0.36 | 1.47 | 0.20 | 1.94 | 3.01 | 4.29 | 0.00 | 1.23 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 7.11 | 1.08 | 0.00 | 0.20 | 0.83 | 3.33 | 0.00 | 1.25 |
| PA2G4 | ENSG00000170515 | 2.22 | 0.76 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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