Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| F13A1 | ENSG00000124491 | 1.11 | 1.78 | 0.52 | 1.09 | 2.86 | 0.32 | 0.00 | 0.55 | 2.06 | 1.59 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 0.56 | 4.33 | 3.22 | 0.00 | 0.74 | 0.57 | 1.12 | 0.41 | 0.78 | 0.86 | 4.74 | 2.44 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| GPLD1 | ENSG00000112293 | 0.00 | 1.27 | 0.52 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.32 | 1.93 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 4.03 | 0.54 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| TNXB | ENSG00000168477 | 1.11 | 5.09 | 1.03 | 1.82 | 0.00 | 5.48 | 0.00 | 3.31 | 0.26 | 2.39 | 1.54 | 0.54 | 1.42 | 0.00 | 1.37 | 1.67 | 3.01 | 6.01 | 0.00 | 0.98 | 1.72 | 0.56 | 1.43 | 2.34 | 1.29 | 13.98 | 4.07 | 0.69 | 0.00 | 0.83 | 4.21 | 1.82 | 0.00 |
| EGFL8 | ENSG00000241404 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.41 | 0.00 | 0.22 | 0.00 | 0.00 |
| CRISP1 | ENSG00000124812 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 1.32 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| EYS | ENSG00000188107 | 4.44 | 2.29 | 1.96 | 5.84 | 2.86 | 8.06 | 5.41 | 11.05 | 0.26 | 3.59 | 0.00 | 1.63 | 1.42 | 0.00 | 0.00 | 4.72 | 7.16 | 6.44 | 0.00 | 0.25 | 1.15 | 0.56 | 0.61 | 3.91 | 0.86 | 2.13 | 3.25 | 1.39 | 0.00 | 0.00 | 6.87 | 1.82 | 0.00 |
| LPA | ENSG00000198670 | 0.00 | 3.82 | 1.14 | 1.46 | 0.00 | 3.23 | 0.00 | 4.42 | 1.55 | 2.19 | 0.00 | 1.08 | 1.42 | 0.74 | 0.20 | 1.11 | 6.40 | 5.79 | 0.00 | 2.70 | 0.57 | 0.56 | 0.61 | 3.91 | 0.86 | 12.09 | 1.90 | 0.69 | 0.00 | 0.00 | 3.33 | 1.82 | 0.00 |
| CPVL | ENSG00000106066 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.00 | 1.32 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| FKBP9 | ENSG00000122642 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.32 | 5.41 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| AEBP1 | ENSG00000106624 | 1.11 | 0.76 | 0.31 | 1.46 | 0.00 | 1.29 | 0.00 | 2.76 | 0.52 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 1.39 | 3.01 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| COL1A2 | ENSG00000164692 | 1.11 | 2.04 | 1.03 | 1.46 | 0.00 | 2.90 | 0.00 | 1.66 | 3.09 | 4.18 | 0.00 | 1.63 | 1.07 | 0.00 | 0.78 | 0.83 | 5.08 | 7.08 | 0.00 | 1.72 | 1.72 | 0.00 | 0.61 | 3.91 | 0.00 | 6.64 | 4.07 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| TRIM4 | ENSG00000146833 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| GDF10 | ENSG00000266524 | |||||||||||||||||||||||||||||||||
| GDF2 | ENSG00000263761 | |||||||||||||||||||||||||||||||||
| KLK9 | ENSG00000213022 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PIP | ENSG00000159763 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPAG11B | ENSG00000164871 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FGF17 | ENSG00000158815 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PXDNL | ENSG00000147485 | 2.22 | 3.82 | 1.45 | 2.92 | 2.86 | 5.16 | 5.41 | 4.42 | 1.03 | 4.38 | 0.00 | 0.54 | 1.42 | 0.00 | 0.20 | 3.89 | 13.37 | 9.87 | 1.23 | 2.45 | 1.15 | 0.00 | 0.20 | 3.91 | 0.86 | 13.98 | 4.61 | 0.69 | 0.20 | 0.00 | 3.99 | 3.64 | 0.00 |
| GGH | ENSG00000137563 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.32 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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