Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PRSS42 | ENSG00000178055 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| LAMB2 | ENSG00000172037 | 0.00 | 2.54 | 1.14 | 2.19 | 0.00 | 0.65 | 0.00 | 1.66 | 1.03 | 1.00 | 0.00 | 0.54 | 1.07 | 1.47 | 0.00 | 1.94 | 2.45 | 2.36 | 0.00 | 0.98 | 0.57 | 0.56 | 0.20 | 1.56 | 0.43 | 3.08 | 1.36 | 0.00 | 0.00 | 0.00 | 5.10 | 0.00 | 0.00 |
| HYAL1 | ENSG00000114378 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ITIH4 | ENSG00000055955 | 1.11 | 1.27 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.54 | 0.00 | 1.47 | 0.39 | 1.11 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 1.82 | 0.00 |
| THPO | ENSG00000090534 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.41 | 0.00 | 0.44 | 0.00 | 0.00 |
| CHRD | ENSG00000090539 | 1.11 | 2.04 | 0.52 | 0.00 | 0.00 | 1.61 | 0.00 | 2.21 | 0.00 | 1.99 | 1.54 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 2.07 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 2.34 | 0.86 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| IGHG2 | ENSG00000211893 | 0.00 | 1.78 | 0.10 | 0.00 | 0.00 | 1.29 | 18.92 | 0.00 | 0.26 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FETUB | ENSG00000090512 | 0.00 | 1.27 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.75 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SST | ENSG00000157005 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CPN2 | ENSG00000178772 | 0.00 | 1.53 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 0.94 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| FGFBP1 | ENSG00000137440 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IGFBP7 | ENSG00000163453 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SPARCL1 | ENSG00000152583 | 1.11 | 1.53 | 0.52 | 1.09 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| HMGCS1 | ENSG00000112972 | 0.00 | 1.78 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 1.11 | 1.32 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CCL28 | ENSG00000151882 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FST | ENSG00000134363 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PDE4D | ENSG00000113448 | 0.00 | 0.76 | 0.93 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.78 | 1.39 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 1.56 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.83 | 1.33 | 1.82 | 1.25 |
| IL5 | ENSG00000113525 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PCYOX1L | ENSG00000145882 | 0.00 | 1.27 | 0.21 | 1.46 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.28 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.83 | 0.44 | 0.00 | 0.00 |
| ARSI | ENSG00000183876 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 1.54 | 0.54 | 0.71 | 0.00 | 0.39 | 1.11 | 1.13 | 0.64 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.69 | 0.41 | 0.83 | 1.33 | 0.00 | 0.00 |
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