Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SERPINE2 | ENSG00000135919 | 0.00 | 0.25 | 0.21 | 0.36 | 2.86 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 1.51 | 0.43 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| SPINT1 | ENSG00000166145 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ECEL1 | ENSG00000171551 | 1.11 | 0.00 | 0.52 | 0.73 | 0.00 | 1.29 | 0.00 | 1.66 | 1.55 | 0.60 | 1.54 | 0.27 | 0.71 | 0.00 | 0.39 | 1.11 | 1.32 | 1.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 1.63 | 0.00 | 0.20 | 0.00 | 0.44 | 1.82 | 0.00 |
| AGRN | ENSG00000188157 | 0.00 | 2.29 | 0.31 | 1.82 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 0.80 | 1.54 | 1.36 | 0.71 | 0.00 | 0.20 | 0.56 | 1.88 | 1.50 | 2.47 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 3.08 | 1.63 | 0.00 | 0.00 | 0.00 | 2.00 | 3.64 | 1.25 |
| ENOX1 | ENSG00000120658 | 0.00 | 1.02 | 0.41 | 0.73 | 0.00 | 0.65 | 5.41 | 1.10 | 0.52 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 2.82 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 2.13 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC12A6 | ENSG00000140199 | 0.00 | 1.53 | 0.41 | 1.09 | 2.86 | 1.29 | 2.70 | 0.55 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 1.88 | 2.58 | 1.23 | 0.49 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 3.08 | 0.54 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| CSPG5 | ENSG00000114646 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.56 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SSR1 | ENSG00000124783 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 5.41 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MST1R | ENSG00000164078 | 0.00 | 4.07 | 0.41 | 3.28 | 0.00 | 1.94 | 2.70 | 1.10 | 1.80 | 1.59 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 1.11 | 1.32 | 1.29 | 0.00 | 1.72 | 1.15 | 0.00 | 0.20 | 0.00 | 0.86 | 2.84 | 0.54 | 0.00 | 0.20 | 0.83 | 2.44 | 0.00 | 0.00 |
| ATP7B | ENSG00000123191 | 0.00 | 2.04 | 0.52 | 1.46 | 0.00 | 0.65 | 0.00 | 1.10 | 1.03 | 1.59 | 0.00 | 1.08 | 1.78 | 0.74 | 0.39 | 0.28 | 2.64 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 4.27 | 0.81 | 0.69 | 0.20 | 0.83 | 1.77 | 0.00 | 0.00 |
| CDH3 | ENSG00000062038 | 1.11 | 1.53 | 0.21 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 1.59 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| EPHB2 | ENSG00000133216 | 0.00 | 2.29 | 0.62 | 1.46 | 0.00 | 1.29 | 2.70 | 1.66 | 1.03 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 1.32 | 1.29 | 1.23 | 0.74 | 1.15 | 0.00 | 0.41 | 0.00 | 0.43 | 5.92 | 1.63 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| TNFRSF11A | ENSG00000141655 | 1.11 | 0.25 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 1.32 | 2.36 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ENPP1 | ENSG00000197594 | 0.00 | 1.53 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.79 | 0.00 | 0.27 | 1.42 | 0.00 | 0.59 | 0.28 | 2.26 | 4.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.61 | 1.08 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| MC1R | ENSG00000258839 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FKRP | ENSG00000181027 | 1.11 | 0.76 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNJ14 | ENSG00000182324 | 0.00 | 1.02 | 0.21 | 0.00 | 2.86 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.83 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| GRIN2D | ENSG00000105464 | 1.11 | 2.04 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.00 | 0.71 | 0.74 | 0.39 | 0.83 | 1.51 | 1.93 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.90 | 0.81 | 0.00 | 0.41 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC7A6 | ENSG00000103064 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| TRPM4 | ENSG00000130529 | 1.11 | 1.27 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 1.66 | 0.77 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.56 | 1.88 | 1.50 | 1.23 | 0.74 | 1.15 | 0.00 | 0.61 | 1.56 | 0.86 | 4.03 | 1.63 | 0.00 | 0.41 | 0.00 | 3.33 | 1.82 | 0.00 |
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