Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PRSS41 | ENSG00000215148 | |||||||||||||||||||||||||||||||||
| ADAMTS14 | ENSG00000138316 | 0.00 | 2.29 | 0.31 | 1.46 | 0.00 | 1.61 | 0.00 | 1.66 | 0.00 | 1.99 | 0.00 | 1.36 | 1.07 | 0.00 | 0.20 | 1.67 | 3.95 | 1.72 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 2.84 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MMRN2 | ENSG00000173269 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.00 | 0.94 | 0.64 | 1.23 | 0.49 | 1.15 | 0.00 | 0.61 | 1.56 | 0.86 | 2.13 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| LIPK | ENSG00000204021 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| LIPN | ENSG00000204020 | 1.11 | 0.25 | 0.62 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR1P1 | ENSG00000262085 | |||||||||||||||||||||||||||||||||
| LIPA | ENSG00000107798 | 0.00 | 0.76 | 0.21 | 0.36 | 2.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IDE | ENSG00000119912 | 0.00 | 1.27 | 0.52 | 1.82 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.54 | 1.07 | 0.74 | 0.00 | 1.67 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| SLK | ENSG00000065613 | 1.11 | 2.54 | 0.31 | 0.73 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.80 | 3.08 | 1.36 | 0.71 | 0.00 | 0.78 | 0.83 | 1.88 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| OR1D4 | ENSG00000255095 | |||||||||||||||||||||||||||||||||
| DEAF1 | ENSG00000177030 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 1.03 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| MUC5B | ENSG00000117983 | 0.00 | 7.12 | 2.79 | 4.74 | 5.71 | 6.13 | 8.11 | 6.63 | 2.32 | 7.37 | 0.00 | 1.08 | 1.78 | 0.74 | 1.76 | 5.28 | 7.34 | 11.80 | 2.47 | 1.23 | 1.15 | 1.69 | 1.02 | 5.47 | 1.72 | 11.14 | 4.88 | 2.78 | 1.02 | 0.83 | 13.30 | 0.00 | 0.00 |
| OLFML1 | ENSG00000183801 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OVCH2 | ENSG00000183378 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SAA4 | ENSG00000148965 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TCN1 | ENSG00000134827 | 0.00 | 1.27 | 0.41 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 1.03 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR3A4P | ENSG00000180068 | |||||||||||||||||||||||||||||||||
| GPHA2 | ENSG00000149735 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC22A20 | ENSG00000197847 | |||||||||||||||||||||||||||||||||
| CTSC | ENSG00000109861 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.83 | 0.67 | 1.82 | 0.00 |
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