Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PTPN3 | ENSG00000070159 | 0.00 | 2.29 | 0.52 | 0.36 | 0.00 | 0.65 | 2.70 | 1.10 | 1.55 | 1.00 | 1.54 | 0.27 | 0.71 | 0.00 | 0.00 | 1.11 | 1.32 | 1.72 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| OR4C16 | ENSG00000279514 | |||||||||||||||||||||||||||||||||
| SERPINA7 | ENSG00000123561 | 1.11 | 0.00 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.88 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.00 | 4.98 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| DNASE1L1 | ENSG00000013563 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CA6 | ENSG00000131686 | 0.00 | 0.51 | 0.10 | 0.73 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLOD1 | ENSG00000083444 | 0.00 | 0.51 | 0.21 | 0.36 | 2.86 | 1.29 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 1.47 | 0.20 | 0.28 | 0.94 | 1.50 | 0.00 | 1.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CELA3B | ENSG00000219073 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR5R1 | ENSG00000279961 | |||||||||||||||||||||||||||||||||
| PODN | ENSG00000174348 | 0.00 | 1.02 | 0.72 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 1.32 | 1.07 | 0.00 | 1.96 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| PDE4B | ENSG00000184588 | 1.11 | 1.02 | 0.72 | 1.46 | 2.86 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 2.07 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.20 | 0.83 | 0.44 | 0.00 | 0.00 |
| OLFM3 | ENSG00000118733 | 0.00 | 1.78 | 0.10 | 0.36 | 2.86 | 0.97 | 0.00 | 1.10 | 0.00 | 2.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 3.01 | 3.43 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 3.55 | 2.71 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| COL11A1 | ENSG00000060718 | 1.11 | 5.34 | 1.24 | 2.55 | 0.00 | 4.84 | 8.11 | 8.29 | 1.55 | 8.96 | 0.00 | 2.17 | 1.07 | 0.00 | 0.39 | 5.28 | 16.95 | 15.88 | 0.00 | 3.19 | 2.30 | 0.56 | 2.44 | 2.34 | 0.43 | 14.45 | 7.05 | 0.69 | 0.20 | 0.83 | 6.87 | 5.45 | 0.00 |
| OR1S1 | ENSG00000280204 | |||||||||||||||||||||||||||||||||
| ECM1 | ENSG00000143369 | 0.00 | 1.78 | 0.62 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.83 | 1.11 | 1.82 | 0.00 |
| APCS | ENSG00000132703 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.88 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRG4 | ENSG00000116690 | 0.00 | 2.29 | 0.83 | 2.19 | 0.00 | 0.65 | 0.00 | 1.66 | 0.77 | 1.39 | 0.00 | 0.81 | 0.00 | 0.74 | 0.78 | 0.83 | 3.58 | 2.79 | 1.23 | 0.25 | 0.57 | 0.56 | 0.61 | 1.56 | 0.86 | 2.84 | 1.36 | 0.69 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| REN | ENSG00000143839 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GREM2 | ENSG00000180875 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 0.94 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PIP4K2A | ENSG00000150867 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 1.25 |
| OR8G2P | ENSG00000181214 |
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