Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ARTN | ENSG00000117407 | 1.11 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| C8A | ENSG00000157131 | 0.00 | 1.53 | 0.31 | 0.00 | 0.00 | 0.97 | 2.70 | 1.10 | 0.77 | 1.39 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 1.11 | 2.82 | 2.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 6.87 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| S100A12 | ENSG00000163221 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| S100A8 | ENSG00000143546 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ANGPTL1 | ENSG00000116194 | 0.00 | 0.25 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.20 | 0.83 | 0.44 | 0.00 | 0.00 |
| PTGS2 | ENSG00000073756 | 1.11 | 1.53 | 0.52 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR8B4 | ENSG00000280090 | |||||||||||||||||||||||||||||||||
| SSTR3 | ENSG00000278195 | |||||||||||||||||||||||||||||||||
| IL24 | ENSG00000162892 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| CR1L | ENSG00000197721 | 0.00 | 1.27 | 0.41 | 1.46 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.39 | 0.83 | 1.88 | 2.58 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| ACKR4 | ENSG00000129048 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| NMT2 | ENSG00000152465 | 0.00 | 1.02 | 0.21 | 1.82 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 1.54 | 1.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR14L1P | ENSG00000198452 | |||||||||||||||||||||||||||||||||
| MINPP1 | ENSG00000107789 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LIPM | ENSG00000173239 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2T11 | ENSG00000279301 | |||||||||||||||||||||||||||||||||
| HRAS | ENSG00000174775 | 0.00 | 4.33 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 5.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.50 | 0.00 | 0.00 | 0.00 | 10.11 | 0.81 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 3.46 | 8.26 | 0.67 | 0.00 | 0.00 |
| OR10A6 | ENSG00000279000 | |||||||||||||||||||||||||||||||||
| OR52Z1 | ENSG00000176748 | |||||||||||||||||||||||||||||||||
| OR51B2 | ENSG00000279012 |
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