Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| FUCA2 | ENSG00000001036 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SOSTDC1 | ENSG00000171243 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| BMPER | ENSG00000164619 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 1.59 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 1.39 | 2.45 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 3.13 | 0.43 | 8.29 | 1.36 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| OR4M2 | ENSG00000274102 | |||||||||||||||||||||||||||||||||
| OR13C5 | ENSG00000277556 | |||||||||||||||||||||||||||||||||
| OR13C2 | ENSG00000276119 | |||||||||||||||||||||||||||||||||
| ADAMDEC1 | ENSG00000134028 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 7.82 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| COL14A1 | ENSG00000187955 | 1.11 | 4.83 | 1.65 | 1.09 | 0.00 | 2.26 | 2.70 | 2.21 | 2.06 | 4.78 | 1.54 | 1.08 | 1.07 | 0.00 | 0.78 | 1.11 | 6.21 | 3.65 | 0.00 | 1.72 | 1.15 | 0.00 | 0.00 | 0.78 | 0.43 | 9.95 | 3.25 | 0.69 | 0.00 | 0.83 | 2.44 | 0.00 | 3.75 |
| OR51J1 | ENSG00000184321 | |||||||||||||||||||||||||||||||||
| OR2AG1 | ENSG00000279486 | |||||||||||||||||||||||||||||||||
| ADAMTSL1 | ENSG00000178031 | 0.00 | 4.07 | 1.34 | 2.55 | 0.00 | 2.26 | 0.00 | 2.76 | 0.77 | 1.99 | 3.08 | 0.54 | 0.00 | 0.74 | 0.59 | 1.94 | 4.90 | 2.58 | 0.00 | 1.72 | 0.57 | 0.00 | 0.81 | 1.56 | 0.43 | 4.50 | 2.44 | 1.39 | 0.00 | 0.00 | 5.32 | 3.64 | 2.50 |
| OMD | ENSG00000127083 | 1.11 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.74 | 0.57 | 0.56 | 0.20 | 1.56 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR6Q1 | ENSG00000279051 | |||||||||||||||||||||||||||||||||
| FCN2 | ENSG00000160339 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 1.61 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.88 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTGDS | ENSG00000107317 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| BTK | ENSG00000010671 | 0.00 | 1.27 | 0.62 | 2.19 | 0.00 | 0.65 | 5.41 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.20 | 3.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| PLCH2 | ENSG00000149527 | 0.00 | 2.04 | 0.31 | 0.73 | 0.00 | 2.26 | 2.70 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.39 | 0.28 | 1.13 | 1.07 | 0.00 | 0.25 | 0.57 | 0.00 | 0.81 | 0.00 | 0.00 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KCNAB2 | ENSG00000069424 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR10D3 | ENSG00000197309 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GUCA2A | ENSG00000197273 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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