Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BPIFB2 | ENSG00000078898 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.61 | 0.00 | 1.10 | 1.03 | 1.39 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 1.32 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 2.34 | 0.00 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| BPIFB3 | ENSG00000186190 | 0.00 | 1.53 | 0.00 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| BPIFB1 | ENSG00000125999 | 0.00 | 0.25 | 0.52 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| ASIP | ENSG00000101440 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPINT4 | ENSG00000149651 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TNFRSF6B | ENSG00000243509 | 1.11 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| BPIFC | ENSG00000184459 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 2.70 | 1.66 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 8.09 | 0.20 | 0.83 | 2.07 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.37 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| RAF1 | ENSG00000132155 | 0.00 | 0.76 | 0.52 | 0.00 | 0.00 | 0.97 | 5.41 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.28 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLA1A | ENSG00000144837 | 0.00 | 0.51 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 0.94 | 1.72 | 1.23 | 0.98 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SERPINI2 | ENSG00000114204 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 1.69 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 7.35 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| IL21 | ENSG00000138684 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.57 | 0.56 | 0.41 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GDNF | ENSG00000168621 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR14A2 | ENSG00000241128 | |||||||||||||||||||||||||||||||||
| SPINK14 | ENSG00000196800 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FGF18 | ENSG00000156427 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| C2 | ENSG00000166278 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| OR2AJ1 | ENSG00000177275 | |||||||||||||||||||||||||||||||||
| IL17F | ENSG00000112116 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.00 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR52E5 | ENSG00000277932 | |||||||||||||||||||||||||||||||||
| RSPO3 | ENSG00000146374 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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